Regenerative Medicine and Plastic Surgery: Elements, Research Concepts and Emerging Technologies

Description

This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine Front Matter ....Pages i-xxi Front Matter ....Pages 1-1 Definitions (Dominik Duscher, Matthias M. Aitzetmüller, Elizabeth A. Brett)....Pages 3-3 History of Regenerative Medicine (Maximilian Zaussinger, Dominik Duscher)....Pages 5-6 Basic Principles and Current Approach for Soft Tissue Regeneration (Matthias M. Aitzetmüller, Elizabeth A. Brett, Matthias Sauter, Dominik Duscher)....Pages 7-15 Sophisticated Biocomposite Scaffolds from Renewable Biomaterials for Bone Tissue Engineering (Yavuz Emre Arslan, Eren Ozudogru, Tugba Sezgin Arslan, Burak Derkus, Emel Emregul, Kaan C. Emregul)....Pages 17-31 Front Matter ....Pages 33-33 Mechanotransduction in Wound Healing and Scar Formation (Dominik Duscher)....Pages 35-45 Stromal Cell-Derived Factor 1 (SDF-1) Signaling and Tissue Homeostasis (Zeshaan N. Maan, Mimi R. Borrelli, Khosrow Siamak Houschyar, Geoffrey C. Gurtner)....Pages 47-59 Stem Cell Differentiation Directed by Material and Mechanical Cues (Caitlyn A. Moore, Alexandra Condé-Green, Pranela Rameshwar, Mark S. Granick)....Pages 61-67 Bacteriophages: A New (Yet Old) Weapon Against Infections (Stephen K. Mathew, Reba Kanungo)....Pages 69-79 Bacteriophages as Biocontrol Agents of Biofilm Infections Associated with Abiotic Prosthetic Devices (Shilpa Deshpande Kaistha, Pramila Devi Umrao, Ravish Katiyar, Neelima Deshpande)....Pages 81-99 Extracellular Vesicles Derived from Mesenchymal Stem/Stromal Cells: Current Approaches to Enhance Their Release and Therapeutic Potential (Richard Schäfer, Benjamin Koch, Patrick C. Baer)....Pages 101-111 Anti-Biofilm Activity of Viruses, Bacteria, Fungi, and Lichens: Mechanisms and Impact on Clinical Practice (Oana Săndulescu, Anca Streinu-Cercel, Mihai Săndulescu, Adrian Streinu-Cercel)....Pages 113-122 Front Matter ....Pages 123-123 Bionic Reconstruction: The New Frontier (Stefan Salminger, Johannes A. Mayer, Oskar C. Aszmann)....Pages 125-128 Carbohydrates in Regenerative Medicine: From Scaffolds to Cell Fate Modulators (Roberto Guizzardi, Mattia Vacchini, Laura Cipolla)....Pages 129-149 Biomimetics: A New Abstraction for Bone Implant Design (Elizabeth A. Brett, Matthias A. Sauter, Dominik Duscher)....Pages 151-157 The Role of Microbiota in Skin Regeneration (Angela Faga, Marco Mario Tresoldi, Giovanni Nicoletti)....Pages 159-164 Erythropoietin: An Innovative Therapeutic Approach in Thermal Trauma (Christina Irene Günter, Hans-Günther Machens)....Pages 165-172 Targeting C-Reactive Protein in Inflammatory Disease (Johannes Zeller, Steffen U. Eisenhardt)....Pages 173-186 Stem Cell Therapies for Tissue Regeneration and Wound Healing: Strategies to Enhance Therapeutic Effectiveness (Silvia Mihalceanu, Matthias M. Aitzetmüller, Hans-Günther Machens, Dominik Duscher)....Pages 187-199 Iron Chelators & HIF-1α: A New Frontier for Skin Rejuvenation (Andrea Pagani, Matthias M. Aitzetmüller, Dominik Duscher)....Pages 201-209 Front Matter ....Pages 211-211 How to Overcome the Valley of Death from Basic Science to Clinical Trials (Kelly Bridgham, Akash Chandawarkar, Halley Darrach, Justin M. Sacks)....Pages 213-220 Moving Your Results from Bench to Bedside: Protecting Scientific Findings (Dominik Thor)....Pages 221-227 The Regulatory Landscape of Cell- and Tissue-Based Regenerative Medicine: Current Challenges and Emerging Issues (Sarah Khalid Alageel, Martin Hildebrandt, Ana Valéria Gouveia de Andrade)....Pages 229-243 Translational Challenges in Soft Tissue Regeneration (Juan Liu, Jennifer Ernst, Eric Klingelhoefer, Dominik Saul, Wolfgang Lehmann, Gunter Felmerer et al.)....Pages 245-281 Bone Tissue Engineering Challenges in Craniofacial Reconstructive Surgeries (Seyed Mohammad Zargar, Nima Jamshidi)....Pages 283-292 Translational Challenges: Lymph Node Tissue Engineering (Philipp Neßbach, Matthias M. Aitzetmüller)....Pages 293-301 Implementing Tissue Engineering and Regenerative Medicine Solutions in Silicone Implants (Jae Chul Lee, Chan Yeong Heo)....Pages 303-318 Front Matter ....Pages 319-319 Microdeformational Wound Therapy (Douglas Helm, Dennis P. Orgill)....Pages 321-328 Clinical Treatment of Hypertrophic Scars (Rei Ogawa)....Pages 329-335 Tissue Engineering and Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Clinical Applications of Mesenchymal Stem Cells (Marco Tatullo, Massimo Marrelli, Francesco Paduano, Francesca Palmieri, Sandro Rengo, Carlo Rengo et al.)....Pages 337-348 Reconstruction of Post-Traumatic Maxillary Ridges Using a Radial Forearm Free Flap and Allogeneic Tissue-Engineered Bone Grafts (James C. Melville, Huy Q. Tran, Jonathan W. Shum, Ramzey Tursun, Robert E. Marx)....Pages 349-355 Postoperative Complications of Mandibular Fracture Management (Giuseppe Spinelli, Francesco Arcuri, Domenico Valente, Tommaso Agostini)....Pages 357-363 Use of Porcine Urinary Bladder Matrix (UBM-ECM) in the Head and Neck Region (Bruce A. Kraemer, Amanda Gryniewicz Rowe)....Pages 365-393 Advances in Facial Nerve Paralysis: Surgical Innovation, Tissue Engineering, and Emerging Technology (Julia R. Brennan, Matthew E. Spector, Jennifer C. Kim, Michael J. Brenner)....Pages 395-409 Management of Capsular Contracture: Non-surgical and Surgical Options (Jacob Haiavy, Whitney Florin)....Pages 411-428 Soft Tissue Reconstruction of the Lower Limb (Mahmoud Kazem Nassar, Daniel J. Jordan, Sandip Hindocha)....Pages 429-458 Back Matter ....Pages 459-472