ENGLISH

Genetic Variants in Alzheimer's Disease

By Kevin Morgan , Minerva M. Carrasquillo (auth.) , Minerva M. Carrasquillo (eds.)

Book information

Publisher
Springer-Verlag New York
Year
2013
ISBN
978-1-4614-7308-4, 978-1-4614-7309-1
DOI
10.1007/978-1-4614-7309-1
Language
english
Format
PDF
Filesize
5 MB (5284629 bytes)
Edition
1
Pages
254\256
Orientation
yes
Scanned
yes
Time added
2013-10-21 03:52:09
Human Genetics; Neurosciences; Gene Function

Description

Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s. These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure. The aim of this book is to put all of the recent genetic data on these new genes into context. Different genetic variants will be discussed, as well as biomarkers and future possibilities. ​

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