ENGLISH

VEGF in Development

By Christiana Ruhrberg PhD (auth.)

Book information

Publisher
Springer-Verlag New York
Year
2008
ISBN
978-0-387-78631-5, 978-0-387-78632-2
DOI
10.1007/978-0-387-78632-2
Language
english
Format
PDF
Filesize
4 MB (3985411 bytes)
Series
Molecular Biology Intelligence Unit
Edition
1
Pages
106\115
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Biochemistrygeneral

Description

This book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit. In addition, VEGFA is emerging as a versatile patterning factor for several non-endothelial cell types in vertebrates. Thus, it plays a central role during organ development at multiple levels, including blood vessel growth, vessel-mediated organ induction and tissue differentiation.

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