ENGLISH

Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective

Book information

Year
2012
ISBN
9780470631324, 9781118309872
DOI
10.1002/9781118309872
Language
english
Format
PDF
Filesize
3 MB (2825641 bytes)
Pages
368\368
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs.  The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.Content: Chapter 1 Transition Metal Catalysis in the Pharmaceutical Industry (pages 1–24): Carl A. Busacca, Daniel R. Fandrick, Jinhua J. Song and Chris H. SenanayakeChapter 2 Selected Applications of Transition Metal?Catalyzed Carbon–Carbon Cross?Coupling Reactions in the Pharmaceutical Industry (pages 25–95): Hong C. ShenChapter 3 Selected Applications of Pd? and Cu?Catalyzed Carbon–Heteroatom Cross?Coupling Reactions in the Pharmaceutical Industry (pages 97–163): Jingjun YinChapter 4 Asymmetric Cross?Coupling Reactions (pages 165–213): Vince Yeh and William A. SzaboChapter 5 Metathesis Reactions (pages 215–255): Oliver R. ThielChapter 6 Transition Metal?Catalyzed Synthesis of Five? and Six?Membered Heterocycles (pages 257–275): Cheol K. Chung and Matthew L. CrawleyChapter 7 Oxidative Catalysis (pages 277–314): Lamont TerrellChapter 8 Industrial Asymmetric Hydrogenation (pages 315–342): Hans?Ulrich Blaser

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