ENGLISH

Absorption and Drug Development: Solubility, Permeability, and Charge State, Second Edition

By Alex Avdeef(auth.)

Book information

Year
2012
ISBN
9781118057452, 9781118286067
DOI
10.1002/9781118286067
Language
english
Format
PDF
Filesize
13 MB (13781929 bytes)
Pages
734\734
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

Explains how to perform and analyze the results of the latest physicochemical methodsWith this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates.This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research groupTwo new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrierExpanded information and methods to support pKa determinationNew examples explaining the treatment of practically insoluble test compoundsAdditional case studies demonstrating the use of the latest physicochemical techniquesNew, revised, and expanded database tables throughout the bookWell over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book.This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.Content: Chapter 1 Introduction (pages 1–11): Chapter 2 Transport Model (pages 12–30): Chapter 3 pKa Determination (pages 31–173): Chapter 4 Octanol–Water Partitioning (pages 174–219): Chapter 5 Liposome–Water Partitioning (pages 220–250): Chapter 6 Solubility (pages 251–318): Chapter 7 Permeability—PAMPA (pages 319–498): Chapter 8 Permeability: Caco?2/MDCK (pages 499–574): Chapter 9 Permeability: Blood–Brain Barrier (pages 575–680): Chapter 10 Summary and Some Simple Approximations (pages 681–684):

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