ENGLISH

Leukemia Stem Cells in Hematologic Malignancies

By Shaoguang Li , Haojian Zhang

Book information

Publisher
Springer Singapore
Year
2019
ISBN
978-981-13-7341-1;978-981-13-7342-8
Language
english
Format
PDF
Filesize
7 MB (6979318 bytes)
Series
Advances in Experimental Medicine and Biology 1143
Edition
1st ed.
Pages
VIII, 229\230
Time added
2019-09-18 12:22:52
Biomedicine; Cancer Research; Stem Cells

Description

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc. Front Matter ....Pages i-viii Signaling Pathways in Leukemic Stem Cells (Lindsay M. Gurska, Kristina Ames, Kira Gritsman)....Pages 1-39 Cellular and Molecular State of Myeloid Leukemia Stem Cells (Xueqin Xie, Mengdie Feng, Qifan Wang, Jiazhen Wang, Rong Yin, Yicun Li et al.)....Pages 41-57 Metabolic Regulations in Hematopoietic Stem Cells (Dan Huang, Chiqi Chen, Xiaoxin Hao, Hao Gu, Li Xie, Zhuo Yu et al.)....Pages 59-74 RNA N6-Methyladenosine Modification in Normal and Malignant Hematopoiesis (Hengyou Weng, Huilin Huang, Jianjun Chen)....Pages 75-93 Leukemia Stem Cells in the Pathogenesis, Progression, and Treatment of Acute Myeloid Leukemia (Kanak Joshi, Lei Zhang, Peter Breslin S.J., Jiwang Zhang)....Pages 95-128 Tissue “Hypoxia” and the Maintenance of Leukemia Stem Cells (Persio Dello Sbarba, Giulia Cheloni)....Pages 129-145 DNA Damage Response in Quiescent Hematopoietic Stem Cells and Leukemia Stem Cells (Wenjun Zhang, Guangming Wang, Aibin Liang)....Pages 147-171 Epigenetic Abnormalities in Acute Myeloid Leukemia and Leukemia Stem Cells (Jing Xu, Xiaohang Hang, Baohong Wu, Chong Chen, Yu Liu)....Pages 173-189 Leukemia Stem Cells in Chronic Myeloid Leukemia (Yi Shan, Ngoc DeSouza, Qiang Qiu, Shaoguang Li)....Pages 191-215 Cellular Immunotherapy in the Treatment of Hematopoietic Malignancies (Satoko Matsueda, Thinle Chodon, Richard C. Koya)....Pages 217-229

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