Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and Nanotechnology
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This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well. Contents List of Contributing Authors 1 Methods for the synthesis of oligonucleotides 2 Synthesis of oligonucleotides carrying DNA lesions for DNA repair studies 3 Synthesis of oligonucleotides carrying modified bases for DNA and protein recognition 4 Nonradioactive labeling of oligonucleotides and postsynthetic modification of oligonucleotides 5 Nucleic acids triple helices 6 Nucleic acids quadruplex 7 Advances in therapeutic oligonucleotide chemistry 8 Oligonucleotide conjugates and DNA nanotechnology Index
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