The New Angiotherapy

Description

Angiogenesis, the development of new blood vessels from an existing vascular bed, is an essential feature in many pathological conditions, including cancer, atherosclerosis, rheumatoid arthritis, and diabetic neuropathy. Inadequate regulation of angiogenesis can often lead to chronic pressure ulcers, duodenal ulcers, and myocardial infarction. In The New Angiotherapy, an international team of experts critically review the recent progress in both basic and applied research on angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel angiotherapeutic targets and their use in the clinic. Details of fundamental concepts in angiogenesis physiology and pathophysiology are provided, and the potential of angiotherapy in the management of angiogenic disease is evaluated, highlighting some of the angiogenic and antiangiogenic agents both in development and in clinical trials. The future prospects of receptor antagonists, enzyme inhibitors, and vascular targeted approaches, especially gene therapy in the development of angiotherapy, are also covered. Authoritative and cutting-edge, The New Angiotherapy illuminates our understanding of the central role of human angiogenesis, as well as the novel therapeutic approaches now made possible by our ability to control vascular development. Front Matter....Pages i-xix Front Matter....Pages N1-N1 Vasculogenesis and Angiogenesis....Pages 1-6 Angiogenesis-Regulating Cytokines....Pages 7-40 The Angiopoietins....Pages 41-50 Regulation of Vascular Morphogenesis by Extracellular Matrix Proteins....Pages 51-66 Front Matter....Pages N3-N3 Integrin Receptors and the Regulation of Angiogenesis....Pages 67-79 Vasoactive Peptides in Angiogenesis....Pages 81-104 Angiogenesis in Wound Healing and Surgery....Pages 105-113 Angiogenesis and Vascular Endothelial Growth Factor (VEGF) in Reproduction....Pages 115-128 Rheumatoid Arthritis....Pages 129-149 Diagnostic and Prognostic Significance of Tumor Angiogenesis....Pages 151-176 Front Matter....Pages N5-N5 Hyaluronan Oligosaccharides Promote Wound Repair....Pages 177-188 Role of Thymic Peptides in Wound Healing....Pages 189-197 Angiogenesis and Growth Factors in Ulcer Healing....Pages 199-211 Angiogenesis in Skeletal and Cardiac Muscle....Pages 213-248 Therapeutic Angiogenesis for the Treatment of Cardiovascular Disease....Pages 249-277 Therapeutic Angiogenesis for the Heart....Pages 279-293 Contact-Guided Angiogenesis and Tissue Engineering....Pages 295-313 Front Matter....Pages N9-N9 Inhibitors of Matrix Metalloproteinases....Pages 315-327 Control of Angiogenesis by Microbial Products....Pages 329-355 Interaction of Angiogenic Growth Factors with Endothelial Cell Heparan Sulfate Proteoglycans....Pages 357-385 Front Matter....Pages N9-N9 2-Methoxyestradiol....Pages 387-407 Front Matter....Pages N11-N11 Receptor Tyrosine Kinases in Angiogenesis....Pages 409-452 Targeting Gene Therapy to the Tumor Vasculature....Pages 453-473 Antibody Targeting of Tumor Vasculature....Pages 475-489 Endothelial Monocyte-Activating Polypeptide II....Pages 491-498 CD105 Antibody for Targeting of Tumor Vascular Endothelial Cells....Pages 499-515 Front Matter....Pages N17-N17 Design of Pharmacological and Diagnostic Strategies for Angiogenesis-Dependent Diseases....Pages 517-526 Design of Clinical Trials for Anti-Angiogenics....Pages 527-545 Angiogenesis Therapies....Pages 547-571 Angiostatin and Endostatin....Pages 573-595 Back Matter....Pages 597-609