Progress in Anti-Cancer Chemotherapy

Description

This is the third volume of our series Progress in Anti-Cancer Chemo­ therapy. Following the strategy of the first two volumes, it covers selected aspects of progress in this fast moving field of Oncology, with contribu­ tions from some of the world's best known leaders in both basic and clin­ ical research. This year we focused on seven areas: Three prominent Clinical investigators reviewed conceptual advances in cancer research. Dr Buzdar presented a history and overview of the protection of human subjects who participate in clinical research, and the mechanisms developed to assure the ethical conduct of research on human beings. Frei reviewed an exciting and rapidly moving area of che­ motherapy of solid tumors, including a cogent discussion of the issues related to dose-intensification. Fisher summarized conceptual advances in our therapeutic approach to breast cancer and the paradigm shifts that lead us to our current management strategies. From this summary he pro­ jected breast cancer research into the future, a daunting task under any circumstance. Fundamental research in cancer biology has been responsible for our improved understanding of the development and progession of malignant disease. Such understanding will lead to improved diagnosis, therapy, and eventually, prevention. Isaacs reviews the area of hereditary breast cancer, a topic undergoing rapid transformation and with mUltiple impli­ cations in the daily practice of medicine. Fidler, an international expert in metastasis research reviews the potential utility of angiogenesis inhib­ itors in research and the therapeutic ramifications. Front Matter....Pages i-3 Front Matter....Pages 5-5 Protecting Human Subjects from Risk in the Performance of Clinical Research and the Informed Consent Process....Pages 7-20 Progress and Perspectives in the Chemotherapy of Epithelial Solid Tumors....Pages 21-33 A Personal Perspective About the Future of Breast Cancer Research and Treatment....Pages 34-53 Front Matter....Pages 55-55 Hereditary Breast Cancer: an Overview....Pages 57-80 Clinical Applications of Angiogenesis Inhibitors....Pages 81-96 Front Matter....Pages 57-57 Current Management and New Leads in Small Cell Lung Cancer....Pages 99-108 Progress in Lung Cancer Surgery....Pages 109-130 New Drug Combinations in NSCLC: Progress in Cancer Therapy....Pages 131-174 Front Matter....Pages 175-175 Update in testicular cancer....Pages 177-188 Screening for Prostate Cancer: the good, the bad and the ugly....Pages 189-197 Front Matter....Pages 199-199 The Development of Cancer Vaccines for the Treatment of Metastatic Melanoma....Pages 201-218 The Role of Interferon in the Adjuvant Treatment of Cutaneous Melanoma....Pages 219-230 Front Matter....Pages 231-231 Molecular Mechanisms of Hepatitis B and C Viruses Related Liver Carcinogenesis....Pages 233-245 Epstein-Barr Virus and Malignant Diseases....Pages 246-261 Helicobacter pylori and Malignant Diseases....Pages 262-275 Front Matter....Pages 277-277 High Risk Soft Tissue Sarcoma: an Overview....Pages 279-293 Advances in the Management of Pancreatic Cancer....Pages 294-304