Developmental Endocrinology: From Research to Clinical Practice

Description

Recent advances in molecular endocrinology have significantly increased our understanding of endocrine diseases, as well as that of the medical management of these complicated disorders. In Developmental Endocrinology: From Research to Clinical Practice, leading researchers comprehensively translate all the latest scientific information regarding endocrine physiology and development into an understanding of the clinical pathogenesis, diagnosis, and treatment of these diseases. Organized by endocrine system, each section of the book concisely describes the chronological development of the human organism, from the fetal/prenatal period through childhood, adolescence, and, in some cases, into adulthood. The prenatal sections review recent discoveries concerning transcription factors, homeobox genes, and human molecular mutations- the basic processes governing prenatal development of the individual endocrine organs--and detail the pathophysiology, clinical characteristics, and treatment of pediatric endocrine disorders. Authoritative, comprehensive, and readily accessible, Developmental Endocrinology: From Research to Clinical Practice illuminates for today's medical investigators, basic scientists, and clinicians our rapidly emerging understanding of this complex field, as well as constituting an invaluable guide to the practical clinical management of endocrine diseases. Front Matter....Pages i-x Front Matter....Pages 1-1 Transcriptional Control of the Development and Function of the Hypothalamic-Pituitary Axis....Pages 3-39 Front Matter....Pages 41-41 Molecular Mutations in the Human Growth Hormone Axis....Pages 43-76 Normal and Abnormal Growth....Pages 77-103 Adult Growth Hormone Deficiency....Pages 105-120 Front Matter....Pages 121-121 Molecular Mechanisms of Thyroid Gland Development....Pages 123-134 Fetal-Perinatal Thyroid Physiology....Pages 135-149 Thyroid Disorders in Children and Adolescents....Pages 151-177 Front Matter....Pages 179-179 Genetic Control of Parathyroid Gland Development and Molecular Insights into Hypoparathyroidism....Pages 181-192 Bone Physiology....Pages 193-216 Pediatric Bone Disease....Pages 217-240 Front Matter....Pages 241-241 Transcriptional Development of the Hypothalamic-Pituitary-Gonadal Axis....Pages 243-259 Sexual Differentiation....Pages 261-291 Prenatal Androgens and Sexual Differentiation of Behavior....Pages 293-311 Normal and Precocious Puberty....Pages 313-330 Delayed Puberty....Pages 331-355 Front Matter....Pages 357-357 Molecular Development of the Hypothalamic-Pituitary-Adrenal (HPA) Axis....Pages 359-380 Molecular Genetics of Adrenal Disease....Pages 381-402 Back Matter....Pages 403-421