ENGLISH

Bacterial Lipopolysaccharides: Structure, Chemical Synthesis, Biogenesis and Interaction with Host Cells

By Alba Silipo , Antonio Molinaro (auth.) , Yuriy A. Knirel , Miguel A. Valvano (eds.)

Book information

Publisher
Springer-Verlag Wien
Year
2011
ISBN
9783709107324, 9783709107331
Language
english
Format
PDF
Filesize
12 MB (12270709 bytes)
Edition
1
Pages
440\444
Time added
2020-08-30 06:11:09
Applied Microbiology; Immunology; Medical Biochemi

Description

The bacterial lipopolysaccharide also known as endotoxin is exhaustively covered in the present work. Central emphasis is placed upon the fine chemical structure of the lipopolysaccharide and its significance for understanding their activity and function. In particular, the role it plays in the interaction of bacteria with other biological systems is examined. New aspects of their physicochemical biology are introduced and updates to the current knowledge concerning the lipopolysaccharide are provided. This important class of biomolecules has recently attracted the attention of many investigators, in particular for understanding its involvement in innate immunity, toll-like receptor recognition and intracellular signaling. Front Matter....Pages i-xi Lipid A Structure....Pages 1-20 Structure of the Lipopolysaccharide Core Region....Pages 21-39 Structure of O-Antigens....Pages 41-115 Chemical Synthesis of Lipid A and Analogues....Pages 117-130 Chemical Synthesis of Lipopolysaccharide Core....Pages 131-161 Genetics and Biosynthesis of Lipid A....Pages 163-193 Pathways for the Biosynthesis of NDP Sugars....Pages 195-235 Lipopolysaccharide Core Oligosaccharide Biosynthesis and Assembly....Pages 237-273 Genetics, Biosynthesis and Assembly of O-Antigen....Pages 275-310 Lipopolysaccharide Export to the Outer Membrane....Pages 311-337 Evolution of Lipopolysaccharide Biosynthesis Genes....Pages 339-370 The Molecular Basis of Lipid A and Toll-Like Receptor 4 Interactions....Pages 371-387 Modulation of Lipopolysaccharide Signalling Through TLR4 Agonists and Antagonists....Pages 389-416 Lipopolysaccharide and Its Interactions with Plants....Pages 417-433 Back Matter....Pages 435-440

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