Oral Squamous Cell Carcinoma: From Diagnosis to Treatment
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Contents Preface Chapter 1 Biomarkers in the Progression and Metastasis of Oral Squamous Cell Carcinoma Abstract Introduction Development of Oral Squamous Cell Carcinoma Latest Diagnostic Methods Vital Staining Oral Brush Biopsy Saliva Based OSCC Diagnosis Light-Based Detection System Other Light-Based Detection Systems include Chemiluminescence Based Detection Histological and Cytological Techniques Molecular Analysis Eminence of Biomarkers in OSCC Therapy Identification of Candidate Biomarkers in OSCC Prognostic Biomarkers Predictive Biomarkers Diagnostic Biomarkers Pharmacodynamic Biomarkers Risk Assessment Biomarkers Classification of OSCC Biomarkers Biomarkers in Genomics Single Nucleotide Polymorphisms Chromosomal Rearrangements Epigenetic Modifications as Biomarkers RNA as Biomarkers Proteomic Biomarkers Metabolomic Biomarkers Challenges in OSCC Biomarker Development Conclusion References Chapter 2 Buccal Oral Mucosal Drug Delivery Systems for Treatment and Adjuvant Therapy of Oral Carcinoma Abstract Introduction Definitions and Fundamentals Oral Mucosal Environment in Oral Cancer as a Route for Drug Administration Challenges and Benefits of the Local Treatment of OSCC Suitable Physicochemical and Biopharmaceuticals Characteristics of the Active Pharmaceutical Ingredients Drug Delivery Systems for Local Treatment of Oral Squamous Cell Carcinoma Strategies Technology Pharmaceutical Dosage Forms Safety and Toxicity In Vivo Evaluation In Vitro Evaluation Clinical Trials Patents and Market Conclusion References Chapter 3 Unraveling the Targets of Cancer Stem Cells in Oral Squamous Cell Carcinoma Abstract Introduction Cancer Progression in Oral Squamous Cell Carcinoma (OSCC) Mechanisms for Drug Resistance in Oral CSCs Oral Cancer Stem Cell Markers Diagnostic Approaches in the Determination of CSCs in OSCC Putative Signaling Pathways Triggering the CSCs Proliferation in OSCC Epithelial to Mesenchymal Transition (EMT) and Oral Cancer Stem Cells Future Therapeutics and Possible Clinical Implications of CSCs in OSCC Conclusion References Chapter 4 Diagnostics and Therapeutic Applications of Nanotechnology and Nanomedicine in Oral Squamous Cell Carcinoma Abstract Introduction Oral Cancer Challenges and Limitations in OSCC Treatment Nanotechnology Nanomedicine Cancer Nanotechnology Nanotechnology and OSCC Nanotechnology in OSCC Diagnosis Nanotechnology in OSCC Treatment Nano-Based Drug Delivery for OSCC Clinical Trials of Nanomedicine for OSCC Safety Issues of Nanotechnology Future Perspectives Conclusion References Chapter 5 Biomarkers: A Powerful Armor for Diagnosis of Oral Squamous Cell Carcinoma Abstract Introduction What is a Biomarker? Biomarkers in OSCC Epigenetics p16INK4a Expression in OSCC Proteomics RNA and MicroRNA IL-8 and IL-1B DUSP1 S100 Calcium Binding Protein p Epidermal Growth Factor Receptor Ornithine Decarboxylase Antizyme 1 Clinical Implication of Biomarkers in Detection of OSCC Sensitivity and Specificity of Biomarkers Challenges in Developing a Reliable Biomarker for Detection of OSCC Conclusion References Index Blank Page
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