ENGLISH

Pathogenesis and Treatment of Diabetes Mellitus

By J. K. Radder (auth.) , J. K. Radder , H. H. P. J. Lemkes , H. M. J. Krans (eds.)

Book information

Publisher
Springer Netherlands
Year
1986
ISBN
978-94-010-8411-6, 978-94-009-4301-8
DOI
10.1007/978-94-009-4301-8
Language
english
Format
PDF
Filesize
6 MB (6568327 bytes)
Edition
1
Pages
188\181
Time added
2013-12-12 02:00:00
Internal Medicine; Diabetes

Description

In this book on diabetes mellitus both the pathogenesis and treat­ ment of the disease will be discussed. Pathogenetic studies have led to the distinction between type I and type II diabetes. In type I hyperglycaemia is due predominantly to insulin deficiency; in type II insulin resistance is more important. Three pathogenetic factors are thought to play a role in the etiol­ ogy of type I diabetes: heredity, viral infections and immunity. There may be a relationship between these three aspects since genetic pre­ disposition changes the susceptibility to viral infections and/or the immunological defence against these infections. Insulitis ensues. Auto­ immune processes initiated by this chain of events may contribute to the destruction of the B cells in the islets of Langerhans and diabetes -may eventually follow. This means that at the time of the sudden out­ break of the disease, the destructive process has already been active for years.

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