ENGLISH

Current Topics in Microbiology and Immunology: Ergebnisse der Mikrobiologie und Immunitatsforschung

By H. Koprowski , P. K. Vogt , W. Arber , W. Braun , R. Haas , W. Henle , P. H. Hofschneider , N. K. Jerne , O. Maaløe , R. Rott , M. Sela , E. Wecker (eds.) , P. Koldovsky , H. G. Schweiger , L. Svruček , David W. Kingsbury (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1972
ISBN
978-3-642-65446-6, 978-3-642-65444-2
DOI
10.1007/978-3-642-65444-2
Language
english
Format
PDF
Filesize
6 MB (6747143 bytes)
Series
Current Topics in Microbiology and Immunology 59
Edition
1
Pages
258\249
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
generalgeneral; Biomedicine general; Life SciencesMedicine/Public Health

Description

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve chan­ ges in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune popula­ tion of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRAN­ CIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hem­ agglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism.

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