ENGLISH

Hot-Melt Extrusion: Pharmaceutical Applications

Book information

Year
2012
ISBN
9780470711187, 9780470711415
DOI
10.1002/9780470711415
Language
english
Format
PDF
Filesize
6 MB (6318416 bytes)
Pages
385\385
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

Hot-melt extrusion (HME)  - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include:principles and die design of single screw extrusiontwin screw extrusion techniques and practices in the laboratory and on production scaleHME developments for the pharmaceutical industrysolubility parameters for prediction of drug/polymer miscibility in HME formulationsthe influence of plasticizers in HMEapplications of polymethacrylate polymers in HMEHME of ethylcellulose, hypromellose, and polyethylene oxidebioadhesion properties of polymeric films produced by HMEtaste masking using HMEclinical studies, bioavailability and pharmacokinetics of HME productsinjection moulding and HME processing for pharmaceutical materialslaminar dispersive & distributive mixing with dissolution and applications to HMEtechnological considerations related to scale-up of HME processesdevices and implant systems by HMEan FDA perspective on HME product and process understandingimproved process understanding and control of an HME process with near-infrared spectroscopyHot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science.This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.Content: Chapter 1 Single?Screw Extrusion: Principles (pages 1–21): Keith LukerChapter 2 Twin?screw Extruders for Pharmaceutical Hot?melt Extrusion: Technology, Techniques and Practices (pages 23–42): Dirk Leister, Tom Geilen and Thobias GeisslerChapter 3 Hot?Melt Extrusion Developments in the Pharmaceutical Industry (pages 43–69): Ana Almeida, Bart Claeys, Jean Paul Remon and Chris VervaetChapter 4 Solubility Parameters for Prediction of Drug/Polymer Miscibility in Hot?Melt Extruded Formulations (pages 71–92): Andreas GryczkeChapter 5 The Influence of Plasticizers in Hot?Melt Extrusion (pages 93–112): Geert VerreckChapter 6 Applications of Poly(meth)acrylate Polymers in Melt Extrusion (pages 113–144): Kathrin Nollenberger and Jessica AlbersChapter 7 Hot?Melt Extrusion of Ethylcellulose, Hypromellose and Polyethylene Oxide (pages 145–175): Mark Hall and Michael ReadChapter 8 Bioadhesion Properties of Polymeric Films Produced by Hot?Melt Extrusion (pages 177–199): Joshua Boateng and Dennis DouroumisChapter 9 Taste Masking Using Hot?Melt Extrusion (pages 201–221): Dennis Douroumis, Marion Bonnefille and Attila AranyosChapter 10 Clinical and Preclinical Studies, Bioavailability and Pharmacokinetics of Hot?Melt Extruded Products (pages 223–237): Sandra Guns and Guy Van den MooterChapter 11 Injection Molding and Hot?Melt Extrusion Processing for Pharmaceutical Materials (pages 239–259): Pernille Hoyrup Hemmingsen and Martin Rex OlsenChapter 12 Laminar Dispersive and Distributive Mixing with Dissolution and Applications to Hot?Melt Extrusion (pages 261–284): Costas G. Gogos, Huiju Liu and Peng WangChapter 13 Technological Considerations Related to Scale?Up of Hot?Melt Extrusion Processes (pages 285–300): Adam DreiblattChapter 14 Devices and Implant Systems by Hot?Melt Extrusion (pages 301–321): Andrew LoxleyChapter 15 Hot?Melt Extrusion: An FDA Perspective on Product and Process Understanding (pages 323–331): Abhay Gupta and Mansoor A. KhanChapter 16 Improved Process Understanding and Control of a Hot?Melt Extrusion Process with near?Infrared Spectroscopy (pages 333–353): Chris Heil and Jeffrey Hirsch

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