ENGLISH

Engineering Complex Phenotypes in Industrial Strains

Book information

Year
2012
ISBN
9780470610756, 9781118433034
DOI
10.1002/9781118433034
Language
english
Format
PDF
Filesize
6 MB (6427525 bytes)
Pages
282\282
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

This book highlights current trends and developments in the area of engineering strains. The book details the current and future tools used in the production of bulk chemicals and biofuels from renewable biomass using green technologies. Complex phenotypes are traits in a microbe that requires multiple genetic changes to be modulated simultaneously in the microorganism’s DNA. Knowing what those genetic changes are for a given trait and how to make those changes in the most efficient way forms the motivation behind writing this book. This book explains the newer tools to develop and enable engineered strains at time scales much faster that the natural evolution process so that we can increase a cells' production of a certain substance, increase process productivity, and extend metabolic capability. This book provides a one stop platform of reference for practicing researchers in the field of industrial biotechnology. This book also explains that the commercial success of a process that uses microbial catalysts over platforms that use chemical catalysts and fossil fuels depends on the time it takes to engineer these microbes to perform the desired reaction under harsh manufacturing conditions and at rates that meets the criteria for economic feasibility.Content: Chapter 1 Classical Strain Improvement (pages 1–33): Nathan Crook and Hal S. AlperChapter 2 Tracer?Based Analysis of Metabolic Flux Networks (pages 35–76): Michael DaunerChapter 3 Integration of “Omics” Data with Genome?Scale Metabolic Models (pages 77–109): Stephen Van Dien, Priti Pharkya and Robin OsterhoutChapter 4 Strain Improvement via Evolutionary Engineering (pages 111–131): Byoungjin Kim, Jing Du and Huimin ZhaoChapter 5 Rapid Fermentation Process Development and Optimization (pages 133–168): Jun Sun and Lawrence ChewChapter 6 The Clavulanic Acid Strain Improvement Program at DSM Anti?Infectives (pages 169–183): Bert Koekman and Marcus HansChapter 7 Metabolic Engineering of Recombinant E. coli for the Production of 3?Hydroxypropionate (pages 185–200): Tanya Warnecke Lipscomb, Matthew L. Lipscomb, Ryan T. Gill and Michael D. LynchChapter 8 Complex System Engineering: A Case Study for an Unsequenced Microalga (pages 201–231): Michael T. Guarnieri, Lieve M. L. Laurens, Eric P. Knoshaug, Yat?Chen Chou, Bryon S. Donohoe and Philip T. PienkosChapter 9 Meiotic Recombination?Based Genome Shuffling of Saccharomyces Cerevisiae and Schefferomyces Stiptis for Increased Inhibitor Tolerance to Lignocellulosic Substrate Toxicity (pages 233–250): Dominic Pinel and Vincent J. J. Martin

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