ENGLISH

Immunogenicity of Biopharmaceuticals (Biotechnology: Pharmaceutical Aspects)

By Marco van de Weert

Book information

Publisher
Springer
Year
2008
ISBN
0387758402, 9780387758404
LCC
QR188.4 .I424 2008
Open Library ID
OL17006953M
Language
english
Format
PDF
Filesize
3 MB (3298538 bytes)
Edition
1
Pages
268\269
Scanned
yes
Time added
2012-03-17 06:00:00
Медицинские дисциплины;Фармацевтика;Фармацевтическ

Description

A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen-Ortho s blockbuster product Eprex has increased the attention towards potential immunogenicity of biopharmaceuticals, above all from the regulatory agencies. This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

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