Comparative and Veterinary Pharmacology

Description

The human–animal bond has evolved and diversi?ed down the ages. Dogs, cats and even horses, have long ful?lled the role of faithful companion and indeed, as exempli?ed by the introduction of seeing and hearing dogs, there may be a critical level of co-dependency between the species. In the twenty-?rst century, the animal types that are kept as pets in many parts of the world are extensive ranging from reptiles through rodents to ruminants and beyond. As would be predicted by the nature of the relationship, the approach to treatment of a companion animal is often closely aligned to that which would have been offered to their owner. However, an increasing awareness of welfare issues, such as the recognition that animals expe- ence pain and the proven bene?ts of disease prevention in intensive farming units, together with the growth in zoos and wildlife parks, has increased the likelihood of food producing and non-domesticated animals receiving medicinal products during their life-time. Although many of the individual drugs or classes of drugs administered to animals are the same as, or derived from, those given to man, the safe and effective use of drugs in animals often cannot be achieved by simply transposing knowledge of drug action on, or behaviour in, the body from one species to another. The impact of the anatomical, physiological and pathophysiological variability that spans the animal kingdom can often profoundly alter drug response. Front Matter....Pages i-x Front Matter....Pages 1-1 Introduction....Pages 3-17 Species Differences in Pharmacokinetics and Pharmacodynamics....Pages 19-48 Comparative and Veterinary Pharmacogenomics....Pages 49-77 Drug Delivery Systems in Domestic Animal Species....Pages 79-112 Population Medicine and Control of Epidemics....Pages 113-138 Interspecies Allometric Scaling....Pages 139-157 Pain and Analgesia in Domestic Animals....Pages 159-189 New Technologies for Application to Veterinary Therapeutics....Pages 191-210 Front Matter....Pages 212-212 Genetically Modified Animals and Pharmacological Research....Pages 213-226 Antimicrobial Drug Resistance....Pages 227-264 Drug Residues....Pages 265-290 Veterinary Medicines and the Environment....Pages 291-314 Veterinary Medicines and Competition Animals: The Question of Medication Versus Doping Control....Pages 315-339 Back Matter....Pages 341-348