Comprehensive Cytopathology: Expert Consult: Online

Description

In the newly updated edition of Comprehensive Cytopathology, a team of international experts provides criteria and techniques in diagnosis, testing, and new insights in cytology. This accessible guide to diagnostic investigation and screening is ideal for daily laboratory use, taking a systematic approach to helping you understand major diagnostic criteria as well as the pitfalls and limitations of cytology. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Quickly find the answers you need through a consistent chapter structur.;Front cover; Comprehensive Cytopathology, 4/e; Copyright page; Table of Contents; List of Contributors; Preface; Dedication; Acknowledgments; List of Virtual Images; Guidelines How to View the Slide; 1 General Cytology; 1 The Cell:; Contents; Basic Structure and Function of Mammalian Cells; Overview; Nucleus; Contents of the Nucleus; DNA.; Nuclear Proteins.; Nuclear Morphology; Chromatin.; Hematoxylin; Nucleoli; Nuclear Envelope and Nuclear Shape; Cytoplasm and Plasmalemma; Cytoplasmic Stain; Endoplasmic Reticulum; Golgi Apparatus; Mitochondria; Lysosomes; Cytoskeleton, Centrosome. Front cover Comprehensive Cytopathology, 4/e Copyright page Table of Contents List of Contributors Preface Dedication Acknowledgments List of Virtual Images Guidelines How to View the Slide 1 General Cytology 1 The Cell: Contents Basic Structure and Function of Mammalian Cells Overview Nucleus Contents of the Nucleus DNA. Nuclear Proteins. Nuclear Morphology Chromatin. Hematoxylin Nucleoli Nuclear Envelope and Nuclear Shape Cytoplasm and Plasmalemma Cytoplasmic Stain Endoplasmic Reticulum Golgi Apparatus Mitochondria Lysosomes Cytoskeleton, Centrosome. Cell Membrane, Receptors, and Signal TransductionCell Junctions Cell Growth and Division Influence of Epigenetic Modifications on Gene Expression and Cell Function The Molecular Basis of Neoplasia Overview Principles of Malignant Transformation Cancer-related Genes The Major Pathways of Carcinogenesis Carcinogenesis Induced by Papillomavirus Infections Basic Structure of the Virus and its Genome Epidemiology of HPV Infections The Role of the High-Risk HPV E6 and E7 Genes Progression of HPV-infected Epithelial Cells to Invasive Cancer Cells Concluding Remarks References. 2 Basic Cytogenetics and the Role of Genetics in Cancer DevelopmentContents Introduction Historical Background Basic Knowledge of Cytogenetics Cell Cycle The Interphase The Mitosis Prophase Metaphase Anaphase Telophase The Meiosis The Chromosome Structure Methodology The Karyotype The Standardized Reporting Karyotyping In Situ Hybridization The FICTION Technique Array-based Karyotyping Acquired Chromosomal Aberrations in Cancer Lymphoma Follicular Lymphoma Mantle Cell Lymphoma Marginal Zone B-cell Lymphoma Small Lymphocytic Lymphoma Lymphoplasmacytic Lymphoma. Diffuse Large B-cell LymphomaBurkitt's Lymphoma Anaplastic Large Cell Lymphoma Soft-tissue Tumors Soft-tissue Tumors with Single Karyotypic Abnormalities Soft-tissue Tumors with Complex Karyotypes Carcinomas Thyroid Carcinoma Papillary Thyroid Carcinoma. Follicular Thyroid Carcinoma. Clinical Applications of Conventional Cytogenetics and FISH in Cytology FISH Strategy Application Lymphoma Sarcomas Multiple Myeloma Concluding Remarks References 3 Cytologic Screening Programs Contents Principles of Screening Cervical Cancer and Screening. Cervical Cancer Incidence and Mortality WorldwideEfficacy of Screening Design of Screening Programs Features of Successful Screening Programs Limitations of Screening Programs Errors and Failures in the Program Socioeconomic and Cultural Problems Screening Programs and HPV Vaccine Impacts of HPV Vaccine on Screening Programs Screening Programs and HPV DNA Tests Pros and Cons of HPV Primary Screening The Role of the Laboratory in Screening Programs Early Detection of Cancer in Other Sites New Developments in Cytological Screening Liquid-based Cytology Automated Cytology.