Etiology and Pathophysiology of Parkinson's Disease

Description

InTech, 2011. — 552 p.This book about Parkinson’s disease provides a detailed account of etiology and pathophysiology of Parkinson’s disease, a complicated neurological condition. Environmental and genetic factors involved in the causation of Parkinson’s disease have been discussed in detail. This book can be used by basic scientists as well as researchers. Neuroscience fellows and life science readers can also obtain sufficient information. Beside genetic factors, other pathophysiological aspects of Parkinson’s disease have been discussed in detail. Up to date information about the changes in various neurotransmitters, inflammatory responses, oxidative pathways and biomarkers has been described at length. Each section has been written by one or more faculty members of well known academic institutions. Thus, this book brings forth both clinical and basic science aspects of Parkinson’s disease.Contents Etiology and Pathogenesis of Parkinson’s Disease Genetics of Parkinson Disease Parkin and Parkinson’s Disease Modeling LRRK2 Parkinsonism Alpha-Synuclein Interactions with Membranes Alpha-Synuclein, Oxidative Stress and Autophagy Failure: Dangerous Liaisons in Dopaminergic Neurodegeneration Targeting α-Synuclein-Related Synaptic Pathology: Novel Clues for Parkinson’s Disease Therapy Effects of Alpha-Synuclein on Cellular Homeostasis Actions of GDNF on Midbrain Dopaminergic Neurons: The Signaling Pathway The Hsp70 Chaperone System in Parkinson’s Disease The Noradrenergic System is a Major Component in Parkinson’s Disease The Energy Crisis in Parkinson’s Disease: A Therapeutic Target Analysis of Transcriptome Alterations in Parkinson’s Disease Brain Mitochondrial Dysfunction and Complex I Syndrome in Parkinson´s Disease Role of Microglia in Inflammatory Process in Parkinson’s Disease Oxidative DNA Damage and the Level of Biothiols, and L-Dopa Therapy in Parkinson’s Disease Inflammatory Responses and Regulation in Parkinson’s Disease Mathematical Models: Interactions Between Serotonin and Dopamine in Parkinson’s Disease Dopaminergic Control of the Neurotransmitter Release in the Subthalamic Nucleus: Implications for Parkinson’s Disease Treatment Strategies Possible Contribution of the Basal Ganglia Brainstem System to the Pathogenesis of Parkinson’s Disease Role of Lysosomal Enzymes in Parkinson’s Disease: Lesson from Gaucher’s Disease Physiological and Biomechanical Analyses of Rigidity in Parkinson's Disease Mesothalamic Dopaminergic Activity: Implications in Sleep Alterations in Parkinson's Disease Pathophysiology of Non-Dopaminergic Monoamine Systems in Parkinson's Disease: Implications for Mood Dysfunction