Lysophospholipid Receptors: Signaling and Biochemistry

Description

The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports?ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems?have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling. Lysophospholipid Receptors is divided into three sections: Receptors and other possible effectorsEnzymesPhysiology and pathophysiologyWithin each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics. Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field. Content: Chapter 1 Lysophosphatidic Acid (LPA) Receptor Signaling (pages 1–39): Hope Mirendil, Mu?En Lin and Jerold ChunChapter 2 Sphingosine 1?Phosphate (S1P) Receptors (pages 41–60): Bongnam Jung and Timothy HlaChapter 3 Global Gene Expression Program of Lysophosphatidic Acid (LPA)?Stimulated Fibroblasts (pages 61–69): Catelijne Stortelers and Wouter H. MoolenaarChapter 4 Identification of Direct Intracellular Targets of Sphingosine 1?Phosphate (S1P) (pages 71–83): Nitai C. Hait, Sheldon Milstien and Sarah SpiegelChapter 5 Lysophospholipid Receptor Signaling Platforms: The Receptor Tyrosine Kinase–G Protein?Coupled Receptor Signaling Complex (pages 85–102): Nigel J. Pyne and Susan PyneChapter 6 Autotaxin: A Unique Ecto?Type Pyrophosphodiesterase with Diverse Functions (pages 103–119): Hiroshi Yukiura and Junken AokiChapter 7 Studies on Autotaxin Signaling in Endocytic Vesicle Biogenesis and Embryonic Development Using Whole Embryo Culture and Electroporation (pages 121–136): Masayuki Masu, Seiichi Koike, Takuya Okada and Kazuko Keino?MasuChapter 8 Standardization and Quantification of Lysophosphatidic Acid Compounds by Normal?Phase and Reversed?Phase Chromatography–Tandem Mass Spectrometry (pages 137–151): Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex Brown and Walter A. ShawChapter 9 Sphingosine Kinases: Biochemistry, Regulation, and Roles (pages 153–183): Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham and Stuart M. PitsonChapter 10 Functional and Physiological Roles of Sphingosine 1?Phosphate Transporters (pages 185–200): Atsuo Kawahara and Tsuyoshi NishiChapter 11 Lipid Phosphate Phosphatases and Signaling by Lysophospholipid Receptors (pages 201–227): Ganesh Venkatraman and David N. BrindleyChapter 12 Lipid Phosphate Phosphatases: Recent Progress and Assay Methods (pages 229–263): Andrew J. Morris, Susan S. Smyth, Abdel K. Salous and Andrew D. RenaultChapter 13 Lysophosphatidic Acid (LPA) Signaling and Cardiovascular Pathology (pages 265–281): Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam and Andrew J. MorrisChapter 14 Sphingosine 1?Phosphate (S1P) Signaling in Cardiovascular Physiology and Disease (pages 283–312): Bodo LevkauChapter 15 Sphingosine 1?Phosphate (S1P) Signaling and the Vasculature (pages 313–347): Christian WaeberChapter 16 Regulation of the Nuclear Hormone Receptor Ppar? by Endogenous Lysophosphatidic Acids (LPAS) (pages 349–372): Ryoko Tsukahara, Tamotsu Tsukahara and Gabor TigyiChapter 17 Mechanisms and Models for Elucidating the Cardiac Effects of Sphingosine 1?Phosphate (S1P) (pages 373–397): Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell and Joan Heller BrownChapter 18 Neural Effects of Lysophosphatidic Acid (LPA) Signaling (pages 399–418): Nobuyuki FukushimaChapter 19 Widespread Expression of Sphingosine Kinases and Sphingosine 1?Phosphate (S1P) Lyase Suggests Diverse Functions in the Vertebrate Nervous System (pages 419–432): H. Meng and V. M. LeeChapter 20 Lysophosphatidic Acid and Neuropathic Pain: Demyelination and LPA Biosynthesis (pages 433–449): Hiroshi UedaChapter 21 Role of Lysophosphatidic Acid (LPA) in Behavioral Processes: Implications for Psychiatric Disorders (pages 451–473): Guillermo Estivill?Torrus, Luis Javier Santin, Carmen Pedraza, Estela Castilla?Ortega and Fernando Rodriguez de FonsecaChapter 22 Sphingosine 1?Phosphate (S1P) Signaling and Lymphocyte Egress (pages 475–488): Alejandra Mendoza, Lauren A. Pitt and Susan R. SchwabChapter 23 Biology Revealed by Sphingosine 1?Phosphate (S1P) Receptor Gene?Altered Mice (pages 489–506): Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman Kang, Catherine C. Theisen, Eleanor L. Koerner and Richard L. ProiaChapter 24 Role of Lysophosphatidic Acid (LPA) in the Intestine (pages 507–527): C. Chris Yun and Peijian HeChapter 25 Lysophospholipid Signaling in Female and Male Reproductive Systems (pages 529–567): Xiaoqin YeChapter 26 The Gonads and their Magic Bullet, Lysophosphatidic Acid: Physiological and Toxicological Functions of Lysophosphatidic Acid (LPA) In Female and Male Reproductive Systems (pages 569–585): Lygia Therese Budnik, Barbel Brunswig?Spickenheier and Dieter MullerChapter 27 Lysophospholipid Regulation of Lung Fibrosis (pages 587–607): Barry S. Shea and Andrew M. TagerChapter 28 Lysophosphatidic Acid (LPA) Signaling and Bone (pages 609–625): Jean Pierre Salles, Sara Laurencin?Dalicieux, Francoise Conte?Auriol, Fabienne Briand?Mesange and Isabelle GenneroChapter 29 Lysophosphatidic Acid (LPA) Signaling and Bone Cancer (pages 627–640): Olivier Peyruchaud, Marion David, Timothy L. Macdonald and Kevin R. LynchChapter 30 Understanding the Functions of Lysophosphatidic Acid Receptors in Cancer (pages 641–659): Nattapon Panupinthu and Gordon B. MillsChapter 31 Lysophosphatidic Acid Receptors in Cancer (pages 661–679): Abir Mukherjee, Jinhua Wu, Yongling Gong and Xianjun FangChapter 32 LPA Receptor Subtypes LPA1 and LPA2 as Potential Drug Targets (pages 681–708): Gretchen Bain and T. Jon SeidersChapter 33 Clinical Introduction of Lysophosphatidic Acid (LPA) and Autotaxin Assays (pages 709–735): Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda and Junken AokiChapter 34 Antibodies to Bioactive Lysophospholipids (pages 737–751): Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney and Barbara Visentin