Bone Adaptation: In Silico Approach

Description

This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics. Front Matter ....Pages i-xiv Overview: In Silico Approaches to Understand Bone Adaptation (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 1-11 Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 13-24 Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 25-44 Estimation of Bone Permeability for Poroelastic Analysis (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 45-63 Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 65-81 Effects of Local Bending Load on Trabecular Bone Adaptation (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 83-90 Cancellous Bone Adaptation Predicted by Remodeling Simulations (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 91-101 Trabecular Surface Remodeling Toward Uniform Local Stress State (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 103-119 Spatial and Temporal Regulation of Cancellous Bone Structure by Trabecular Surface Remodeling (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 121-129 Comparison of Mechanical Quantities as Bone Remodeling Stimuli (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 131-144 Trabecular Surface Remodeling Simulation of Cancellous Bone Using Image-Based Voxel Finite Element Models (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 145-161 Functional Adaptation of Cancellous Bone in Human Proximal Femur (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 163-175 3D Trabecular Remodeling in Human Proximal Femur: Approach to Understanding Wolff’s Law (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 177-185 Trabecular Structural Changes in a Vertebral Body with a Fixation Screw (Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi)....Pages 187-203 Back Matter ....Pages 205-209