ENGLISH

Phage Display As a Tool for Synthetic Biology (Nanotechnology Science and Technology Series)

By Santina Carnazza , Salvatore Guglielmino

Book information

Publisher
Nova Science Pub Inc
Year
2010
ISBN
1608769879, 9781608769872, 9781617618253
LCC
TP248.27.M53 C37 2010
Google Books ID
6tcWQwAACAAJ
Open Library ID
OL24013544M
Language
english
Format
PDF
Filesize
1008 kB (1032517 bytes)
Series
Nanotechnology Science and Technology Series
Pages
94\94
Orientation
yes
Scanned
no
Time added
2012-02-04 16:00:00

Description

Phage display can be considered as a practical realisation of an artificial chemical evolution. As such, it is an useful tool for in vitro protein evolution, aimed to identifying new receptors and natural ligands for 'orphan receptors', drug discovery (peptides might act as enzyme inhibitors and receptor agonists or antagonists, or otherwise modulate the enzyme/receptor's biological effect), 'epitope discovery' (a new approach to disease diagnosis and vaccine development), design of DNA-binding proteins, source of new materials, antibody phage and recombinant phage probes, next-generation nano-electronics, targeted therapy, molecular imaging, gene delivery and phage-display vaccination. All this can be regarded as a kind of synthetic biology in that it involves the reshaping and redirecting of natural molecular systems, phage, typically using the tools of protein and genetic engineering.

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