ENGLISH

Unraveling the Exposome: A Practical View

By Sonia Dagnino , Anthony Macherone

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-319-89320-4;978-3-319-89321-1
Language
english
Format
PDF
Filesize
9 MB (9019576 bytes)
Edition
1st ed.
Pages
XII, 447\445
Time added
2019-01-12 07:45:09
Environment; Environmental Health; Ecotoxicology;

Description

This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics. The term “Exposome” describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques- including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies Front Matter ....Pages i-xii Front Matter ....Pages 1-1 Using Exposomics to Assess Cumulative Risks from Multiple Environmental Stressors (Martyn T. Smith, Cliona M. McHale, Rosemarie de la Rosa)....Pages 3-22 The Public Health Exposome (Paul D. Juarez)....Pages 23-61 The U.S. Military and the Exposome (Christopher Bradburne, John A. Lewis)....Pages 63-85 Framing Fetal and Early Life Exposome Within Epidemiology (Jessica E. Laine, Oliver Robinson)....Pages 87-123 Front Matter ....Pages 125-125 Epigenetics and the Exposome (Michelle Plusquin, Nelly D. Saenen, Tim S. Nawrot)....Pages 127-146 Metabonomics (Toby Athersuch)....Pages 147-181 Transcriptomics within the Exposome Paradigm (D. A. Sarigiannis)....Pages 183-214 Front Matter ....Pages 215-215 The Food Exposome (Augustin Scalbert, Inge Huybrechts, Marc J. Gunter)....Pages 217-245 The Dust Exposome (I. R. Schultz, S. Cade, L. J. Kuo)....Pages 247-254 From the Outside In: Integrating External Exposures into the Exposome Concept (Yuxia Cui, David Balshaw)....Pages 255-276 Front Matter ....Pages 277-277 Statistical Models to Explore the Exposome: From OMICs Profiling to ‘Mechanome’ Characterization (Marc Chadeau-Hyam, Roel Vermeulen)....Pages 279-314 Exposome-Wide Association Studies: A Data-Driven Approach for Searching for Exposures Associated with Phenotype (Chirag J. Patel)....Pages 315-336 Front Matter ....Pages 337-337 HERCULES: An Academic Center to Support Exposome Research (Megan M. Niedzwiecki, Gary W. Miller)....Pages 339-348 EXPOsOMICs: Meet-in-the-Middle and Network Perturbation (Christiana A. Demetriou, Davide Degli Esposti, Kristi Pullen Fedinick, Paolo Vineis)....Pages 349-392 Building an Early Life Exposome by Integrating Multiple Birth Cohorts: HELIX (Martine Vrijheid, Lea Maitre)....Pages 393-404 The HEALS Project (D. A. Sarigiannis)....Pages 405-422 Front Matter ....Pages 423-423 Unravelling the Exposome: Conclusions and Thoughts for the Future (Sonia Dagnino)....Pages 425-437 Back Matter ....Pages 439-447

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