The Collectin Protein Family and Its Multiple Biological Activities

Description

The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging activities of Collectins, such as:  ·         Their role in metabolism, and therefore their involvement in lifestyle diseases such as obesity and cardiovascular disease. ·         Their ability to modulate the adaptive immune response, as well as to recognize and trigger apoptosis of cancer cells, which makes them effective in the annihilation of cancer cells with multiple mutations. ·         The regulation of their expression by gonadal steroid hormones implicates them with critical roles in both male and female fertility. ·         Altered levels of Collectins have been associated with various autoimmune diseases. This book brings together current knowledge of the structure, functions and biological activities of Collectins, to describe their integral role in human health. Front Matter Discovering the Role of Mannose-Binding Lectin (MBL) in Innate Immunity: The Early History Mannose-Binding Lectin in Human Health and Disease Activities of MASPs, The Complement Proteases Associated with Collectins and Ficolins Structures of the MASP Proteases and Comparison with Complement C1r and C1s Biological Activities of SP-A and SP-D Against Extracellular and Intracellular Pathogens Surfactant Protein D: A Therapeutic Target for Allergic Airway Diseases Surfactant Protein D in Immune Surveillance Against Cancer Testicular Immune Privilege: A Recently Discovered Domain of Collectins Collectins in Regulation of Feto-Maternal Cross-Talk Bovine Collectins: Role in Health and Disease