ENGLISH

The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics

By PhD (eds.) , Bryan L. Roth (auth.) , Wesley K. Kroeze , Bryan L. Roth MD

Book information

Publisher
Humana Press
Year
2006
ISBN
978-1-58829-568-2, 978-1-59745-080-5
DOI
10.1007/978-1-59745-080-5
Language
english
Format
PDF
Filesize
8 MB (8227637 bytes)
Series
The Receptors
Edition
1
Pages
618\628
Orientation
yes
Scanned
yes
Time added
2013-10-21 06:56:19
Pharmacy

Description

The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction. Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding.

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