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ENGLISH

Mathematical Modeling of Evolution: Volume 2 Fitness Landscape, Red Queen, Evolutionary Enigmas, and Applications to Virology

By Igor M. Rouzine

Book information

Publisher: de Gruyter
Year: 2023
ISBN: 9783110697384, 9783110697315
DOI: 10.1515/9783110697384
Language: english
Format: PDF
Filesize: 21 MB (22033215 bytes)
Series: De Gruyter Series in Mathematics and Life Sciences; 8/2
Pages: 318\322
Library: degruyter.com
Time added: 2023-09-26 18:16:58

Description

This two-volume work focuses on the mathematical aspects of Darwinian evolution starting from the basic model of stochastic evolution of a single isolated locus in the presence of mutation to the multi–locus models of sexual and asexual populations. Volume 2 discusses the inference of fi tness landscape from DNA sequence data, discovery of the evolutionary roles of enygmatic traits, co-evolution of adversarial species, and various applications to virus evolution. Applications to real-life problems for HIV, influenza, and polio virus. Inference of fitness landscape from genomic data, against the noisy background of linkage. The evolutionary puzzles of HIV latency and progression to AIDS.

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