ENGLISH

Evolving methods for macromolecular crystallography: the structural path to the understanding of the mechanisms of action of CBRN agents: [proceedings of the NATO Advanced Study Institute on Evolving Methods for Macromolecular Crystallography: the Structural Path to the Understanding of the Mechanisms of Action of CBRN Agents, Erice, Italy, 19 - 28 May 2005]

By Randy J. Read , Joel L. Sussman

Book information

Publisher
Springer
Year
2007
ISBN
1402063148, 9781402063145
LCC
QD381.9.S87 N383 2005
Open Library ID
OL11634430M
Language
english
Format
PDF
Filesize
5 MB (5631028 bytes)
Series
NATO Science Series II: Mathematics, Physics and Chemistry
Edition
1
Pages
199\199
Topic
Physics
Library
Kingdwarf
Time added
2010-01-07 06:59:20

Description

X-ray crystallography is the pre-eminent technique for visualizing the structures of macromolecules at atomic resolution. These structures are central to understanding the detailed mechanisms of biological processes, and to discovering novel therapeutics using a structure-based approach. As yet, structures are known for only a small fraction of the proteins encoded by human and pathogenic genomes. To counter the myriad modern threats of disease, there is an urgent need to determine the structures of the thousands of proteins whose structure and function remain unknown. This volume draws on the expertise of leaders in the field of macromolecular crystallography to illuminate the dramatic developments that are accelerating progress in structural biology. Their contributions span the range of techniques from crystallization through data collection, structure solution and analysis, and show how modern high-throughput methods are contributing to a deeper understanding of medical problems.

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