ENGLISH

Targeting Notch in Cancer: From the Fruit Fly to the Clinic

By Lucio Miele , Spyros Artavanis-Tsakonas

Book information

Publisher
Springer New York
Year
2018
ISBN
978-1-4939-8857-0, 978-1-4939-8859-4
Language
english
Format
PDF
Filesize
8 MB (8302504 bytes)
Edition
1st ed.
Pages
VIII, 389\391
Time added
2019-01-12 07:29:41
Biomedicine; Cancer Research; Pharmacology/Toxicol

Description

The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected Front Matter ....Pages i-viii Structural Biology of Notch Signaling (Kelly L. Arnett, Tom C. M. Seegar, Stephen C. Blacklow)....Pages 1-33 Noncanonical Notch Signaling (Jyothi Vijayaraghavan, Barbara A. Osborne)....Pages 35-53 Dual Function of Notch Signaling in Cancer: Oncogene and Tumor Suppressor (Ute Koch, Freddy Radtke)....Pages 55-86 Out on the Fringe: Modulation of Notch Signaling by Glycosylation (Keli Xu, Sean E. Egan)....Pages 87-126 Notch Signaling: A Pivot Regulator of Adaptive and Innate Immunity (Takumi Kumai, Paulo C. Rodriguez)....Pages 127-151 Notch in Ovarian Cancer (Emily Gerry, Vivek Singh, Tian-Li Wang)....Pages 153-173 Notch Signaling in Graft-Versus-Host Disease (Lisa M. Minter)....Pages 175-197 Notch Signaling in T-Cell Acute Lymphoblastic Leukemia and Other Hematologic Malignancies (Catherine Hoofd, Vincenzo Giambra, Andrew P. Weng)....Pages 199-225 The Role of Notch in Breast Cancer (Jeffrey C. Bloodworth, Clodia Osipo)....Pages 227-240 Notch in Lung Cancer (Sara L. Sinicropi-Yao, Michael J. Koenig, David P. Carbone)....Pages 241-276 Notch Signaling in Pediatric Soft Tissue Sarcoma (Cristina Cossetti, Alberto Gualtieri, Silvia Pomella, Elena Carcarino, Rossella Rota)....Pages 277-312 Notch Ligands in Hematopoietic Stem Cell Production (Anna Bigas, Cristina Ruiz-Herguido, Rosa Aligué, Lluís Espinosa)....Pages 313-332 Notch Signaling in the Normal Intestine and Intestinal Cancer (Lluís Espinosa, Erika López-Arribillaga, Oriol Bachs, Anna Bigas)....Pages 333-352 Notch Signaling in Estrogen-Dependent Cancers (Judy S. Crabtree)....Pages 353-380 Back Matter ....Pages 381-389

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