ENGLISH

Assessing Magnetic Fluid Hyperthermia: Magnetic Relaxation Simulation, Modeling of Nanoparticle Uptake inside Pancreatic Tumor Cells and in vitro Efficacy

By Ulrich Engelmann

Book information

Year
2019
ISBN
9783945954584
Language
english
Format
PDF
Filesize
12 MB (12782689 bytes)
Series
1
Pages
291\291
Time added
2021-02-13 22:17:58

Description

Introduction......Page 17 Theory of Magnetism......Page 21 Physics of Magnetic Particle Relaxation......Page 35 Physics of Magnetic Particle Imaging......Page 39 Physics of Magnetic Particle Heating......Page 44 Magnetic Fluid Hyperthermia in Tumor Therapy......Page 47 Hydrogels and Rubber Elasticity Theory......Page 54 State of Research......Page 59 Implementation......Page 60 Results and Comparison to Theories......Page 67 Summary and Outlook......Page 76 Magnetic Particle Systems......Page 79 X-Ray Diffractometry......Page 83 Transmission Electron Microscopy......Page 87 Dynamic Light Scattering......Page 91 Iron Concentration Measurements......Page 95 Superconducting Quantum Interference Device Magnetometry......Page 98 Vibrating Sample Magnetometry......Page 107 Particle Properties Summary......Page 110 Magnetic Particle Spectroscopy......Page 113 Magnetic Fluid Hyperthermia......Page 116 Optimizing Particle Heating by Combining Experiment and Simulation......Page 127 Cell Culture Protocol......Page 135 Morphology of Magnetic Particles inside Cells......Page 137 Quantification of Magnetic Particle Uptake Kinetics......Page 146 Magnetic Properties of Internalized Particles......Page 158 Concluding Remarks......Page 161 Magnetic Particle Heating in Model Systems......Page 165 Characterization of Ferrohydrogels......Page 166 Effect of Particle Immobilization on Magnetic Particles Heating......Page 176 Control and Characterization of Agglomerated Magnetic Particles......Page 183 Effect of Particle Agglomeration on Magnetic Particle Heating......Page 195 Magnetic Fluid Hyperthermia Efficacy......Page 199 Experimental Procedure......Page 200 Magnetic Fluid Hyperthermia Effects on Living Cells......Page 203 Concluding Remarks on Intracellular Magnetic Fluid Hyperthermia Applicability......Page 213 Conclusion and Future Directions......Page 217 Appendix......Page 221 Supplementary Information on Chapter 2......Page 222 Supplementary Information on Chapter 4......Page 223 Supplementary Information on Chapter 5......Page 232 Supplementary Information on Chapter 6......Page 238 Supplementary Information on Chapter 7......Page 242 Supplementary Information on Chapter 8......Page 249 Bibliography......Page 257 List of Publications......Page 287 Acknowledgment......Page 289

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