Basic clinical radiobiology

Description

Content: Introduction: the significance of radiobiology and radiotherapy for cancer treatment -- Irradiation-induced damage and the DNA damage response -- Cell death after irradiation: how, when and why cells die -- Quantifying cell kill and cell survival -- Radiation dose-response relationships -- Linear energy transfer and relative biological effectiveness -- Physics of radiation therapy for the radiobiologist -- Tumour growth and respnse to radiation -- Fractionation: the linear-quadratic approach -- The linear-quadratic approach in clinical practice -- Modified fractionation -- Time factors in normal tissue responses to irradiation -- The dose-rate effect -- Pathogenesis of normal tissue side effects -- Stem cells in radiotherapy -- Normal tissue tolerance and the effect of dose inhomogeneities -- The oxygen effect and therapeutic approaches to tumor hypoxia -- The tumour microenvironment and cellular hypoxia responses -- Combined radiotherapy and chemotherapy -- Molecular targeted agents for enhancing tumour response -- Biological individulisation of radiotherapy -- Molecular image guided radiotherapy -- Retreatment tolerance of normal tissues -- Biological response modification of normal tissue reactions: basic principles and pitfalls -- Hadron therapy: the clinical aspects -- Tissue response models -- Second cancers after radiotherapy.