Psoriasis and Psoriatic Arthritis: Pathophysiology, Therapeutic Intervention, and Complementary Medicine

Description

Psoriasis is a life-long chronic autoimmune disease characterized by thick scaly skin lesions and often associated with severe arthritis. In psoriasis, lesions skin cells, keratinocytes, grow too quickly, resulting in thick, white, silvery or red patches on skin. Normal skin cells grow gradually and flake off about every four weeks, but psoriasis causes new skin cells to move rapidly to the surface of the skin in days rather than weeks. Psoriasis symptoms often appear on the elbows, scalp, feet, knees, hands, or lower back, or as flaking or patches on the skin. It is most common in adults, but teenagers and children can also suffer from psoriasis. Psoriasis is not only a skin condition; it is a chronic disease of the immune system. Chronic psoriasis is associated with other health conditions such as psoriatic arthritis, several inflammatory disorders, type 2 diabetes, and cardiovascular disease. This book provides extensive coverage of psoriasis and psoriatic arthritis. It features information on epidemiology and etiology of psoriasis, pathogenesis, genetics of psoriasis, clinical manifestations, and treatment options using cutting-edge drugs including adalimumab and tofacitinib. Natural phytochemicals and nutraceuticals have demonstrated efficacy in ameliorating psoriasis. The book dedicates comprehensive coverage of nutraceutical therapeutic options including antioxidants, bioactive peptides, carotenoids, alpha lipoic acid, curcumin, and whey protein. These inexpensive natural therapeutics are not associated with any known adverse side effects. Content: Epidemiology of psoriasis and psoriatic arthritis / Adarsh MB, Aman Sharma -- Genetics of psoriasis and psoriatic arthritis / Vinod Chandran -- Inflammation in psoriasis and psoriatic arthritis / Latika Gupta and Amita Aggarwal -- Psoriasis and diabetes : an unholy alliance / Satinath Mukhopadhyay, Deep Dutta, Dipyaman Ganguly -- Angiogenesis and roles of adhesion molecules in psoriatic disease / Dr. Saptarshi Mandal and Dr. Asmita Hazra -- Regulatory role of the TH17 cells in the pathogenesis of psoriatic disease / Soumya D. Chakravarty -- Nerve growth factor and its receptor system in rheumatologic diseases and pain management : a new dimension in the pathogenesis and novel drugs in the pipeline / Smriti K Raychaudhuri, Siba P Raychaudhuri -- Psoriasis : clinical spectrum / Chelsea Ma, Smriti K Raychaudhuri, Emanual Maverakis, Siba P Raychaudhuri -- The clinical spectrum of spondyloarthritis / Dr. Joerg Ermann -- Co-morbidities in psoraitic arthritis / Maria J Antonelli & Marina Magrey -- Management of psoriatic arthritis / Siba P Raychaudhuri, Reason Wilken, Debashis Sarkar, Emanual Maverakis, Smriti K Raychaudhuri -- Targeting IL-23/IL-17 axis for the treatment of psoriasis and psoriatic arthritis / Subhashis Banerjee and Philip Mease -- DMARDS treatment in patients with psoriatic arthritis / Rafael Valle-Oñate, Andrea Chaparro -- Topical therapies for psoriasis / Michael Sticherling -- An overview on JAK-STAT pathways in spondyloarthritis / Smriti K Raychaudhuri, Sanchita Raychaudhuri, Debasis Bagchi, Anand Swaroop, Siba P Raychaudhuri -- The concept of total care- multidisciplinary approach for the management of psoriatic disease / Smriti K Raychaudhuri, Debasis Bagchi, Siba P Raychaudhuri -- Nutraceutical components in the treatment of psoriasis and psoriatic arthritis / Urmila Jarouliya, Raj K. Keservani -- Herbal products for the treatment of psoriasis / Anna Herman, and Andrzej P. Herman -- Impact of nutrition and dietary supplementation is psoriasis pathology / Odete Mendes, Mithila Shitut and Jayson Chen.