Exploring Pancreatic Metabolism and Malignancy

Description

This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy. Front Matter ....Pages i-xii Biology of Pancreas and Possible Diseases (Gowru Srivani, Begum Dariya, Batoul Farran, Afroz Alam, Ganji Purnachandra Nagaraju)....Pages 1-25 Pancreatitis: Clinical Aspects of Inflammatory Phenotypes (Nyshadham S. N. Chaitanya, Aramati BM Reddy)....Pages 27-33 Diabetes and Pancreatic Cancer: A Bidirectional Relationship Perspective (Manoj Kumar Gupta, Vemula Sarojamma, Ramakrishna Vadde)....Pages 35-51 Metabolic Adaptations in Diabetes Mellitus and Cancer (Anil Kumar Pasupulati, Nageswara Rao Dunna, Srikanth Talluri)....Pages 53-69 Role of Mitochondria in Pancreatic Metabolism, Diabetes, and Cancer (Noble Kumar Talari, Ushodaya Mattam, Naresh Babu V. Sepuri)....Pages 71-94 Targeting Mitochondrial Enzymes in Pancreatic Cancer (Gowru Srivani, Begum Dariya, Afroz Alam, Ganji Purnachandra Nagaraju)....Pages 95-110 Diabetes with Pancreatic Ductal Adenocarcinoma (Gowru Srivani, Begum Dariya, Afroz Alam, Ganji Purnachandra Nagaraju)....Pages 111-131 Role of Inflammatory Cytokines in the Initiation and Progression of Pancreatic Cancer (Madanraj Appiya Santharam, Vignesh Dhandapani)....Pages 133-156 Perspectives and Molecular Understanding of Pancreatic Cancer Stem Cells (L. Saikrishna, Prameswari Kasa, Saimila Momin, L. V. K. S. Bhaskar)....Pages 157-172 The Role of Hypoxia Inducible Factor-1α in Pancreatic Cancer and Diabetes Mellitus (Saimila Momin, Ganji Purnachandra Nagaraju)....Pages 173-181 Role of Heat Shock Protein 90 in Diabetes and Pancreatic Cancer Management (Pinninti Santosh Sushma, Saimila Momin, Gowru Srivani)....Pages 183-195 Insulin Resistance Is a Common Core Tethered to Diabetes and Pancreatic Cancer Risk (Henu Kumar Verma, L. V. K. S. Bhaskar)....Pages 197-213 Immunotherapy for Diabetogenic Pancreatitis and Pancreatic Cancer: An Update (Sathish Kumar Mungamuri, Anil Kumar Pasupulati, Vijay Aditya Mavuduru)....Pages 215-236 Exosomes: Mediators and Therapeutic Targets of Diabetes and Pancreatic Cancer ( Deepak KGK, Rama Rao Malla)....Pages 237-251 Methods and Models in Exploring Pancreatic Functions (Rama Rao Malla, Seema Kumari, Krishna Chaitanya Amajala, Deepak KGK, Shailender Gugalavath, Prasuja Rokkam)....Pages 253-268