ENGLISH

Emerging Drugs and Targets for Multiple Sclerosis

By Ana Martinez (editor)

Book information

Publisher
Royal Society of Chemistry
Year
2019
ISBN
1788014502, 9781788014502
Language
english
Format
PDF
Filesize
14 MB (14443960 bytes)
Series
Drug Discovery 70
Pages
450\350
Time added
2021-04-15 14:53:44

Description

Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of the disease – demyelination of axons through remyelination therapies. Due to several recent breakthroughs in the understanding of the pathophysiology of MS new targets for remyelination and immunomodulation are rapidly emerging. This book provides a comprehensive overview of drug discovery and development for the molecular basis of the disease, from new targets to drugs currently in clinical development, cellular and animal disease models to biomarkers for diagnosis and assessment in clinical trials. Emerging Drugs and Targets for Multiple Sclerosis is an ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular. Preface Contents Part I: General Information 1 Multiple Sclerosis: Epidemiology, Genetics, Symptoms, and Unmet Needs • Irene Moreno-Torres, Julia Sabín-Muñoz and Antonio García-Merino 2 Genetics of Multiple Sclerosis • Ahmad Abulaban, David A. Hafler and Erin E. Longbrake 3 Biomarkers for Multiple Sclerosis • Amalia Tejeda Velarde, Silvia Medina Heras and Luisa María Villar Guimerans 4 Optical Coherence Tomography in Multiple Sclerosis • Ricardo Alonso and Leila Cohen 5 Experimental In Vivo Models for Drug Discovery in Multiple Sclerosis • Leyre Mestre and Carmen Guaza Part II: New Drugs in Development for Multiple Sclerosis 6 Progressive Multiple Sclerosis: Drug Discovery • Ebtesam Alshehri and Jeffery A. Cohen 7 B Cell-basedTherapies for Multiple Sclerosis • Michael Osherov and Ron Milo 8 Protein Kinase Inhibitors for the Treatment of Multiple Sclerosis • Ana Martinez and Carmen Gil Part III: Remyelinating Therapies 9 Emerging Drugs and Targets for Remyelination in Multiple Sclerosis • Laura J. Wagstaff and Anna Williams 10 Regulation of Oligodendrocyte Differentiation: New Targets for Drug Discovery in Remyelination • Fernando de Castro and Fernando Josa-Prado Part IV: Other Therapeutic Approaches 11 Cannabinoids as a Therapeutic Approach in Multiple Sclerosis • Gareth Pryce and David Baker 12 Sigma Receptors as New Target for Multiple Sclerosis • Marta Rui, Giacomo Rossino, Daniela Rossi and Simona Collina 13 Non-codingRNA and Multiple Sclerosis: New Targets for Drug Discovery • Iñaki Osorio-Querejeta, Maider Muñoz-Cullaand David Otaegui 14 Diet, Gut Microbiome and Multiple Sclerosis • Lacey B. Sell and Javier Ochoa-Repáraz Subject Index

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