Redox Regulation of Differentiation and De-differentiation

Description

Cell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine. Key Features Provides the first summary on this important topic Reviews redox-dependent development of model organisms and single organs Highlights the redox-regulated pathways important for differentiation processes Illustrates the potential of redox medicine Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration Written by leading experts in the field Related Titles Ayyanathan, K., ed. Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 978-1-77188-067-1) Clarke, M. & J. Frampton. Stem Cells: Biology and Application (ISBN 9780-8153-4511-4) Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Wong, E., ed. Autophagy and Signaling (ISBN 978-0-367-65772-7) Cover Half Title Series Page Title Page Copyright Page Contents Preface Contributors Introduction 1 Thiol Redox Regulation: A Brief Historical Overview Development of (In)Vertebrate Model Organisms 2 Redox Regulation of Plant Development 3 Thiol-Disulphide Redox Signalling/Control during the Life Cycle of Pathogenic Trypanosomatids 4 Redox Regulation during Zebrafish Development Development/Differentiation of Vertebrate Tissues 5 The Differential Roles of NOX-Derived Reactive Oxygen Species in Development, Function, and Dysfunction of the Nervous System 6 H2O2 in Morphogenesis and Regeneration 7 Protein S-Nitrosylation in Neuronal Development 8 NADPH Oxidases in Bone Cells Signaling Pathways during Differentiation and Longevity 9 Identification of Redox-Regulated Pathways via Redox Proteomics 10 Glutathione during Development 11 Roles of NRF2 in Quiescence and Differentiation 12 Role of Iron in Cell Differentiation 13 Redox Regulation of Cytoskeletal Dynamics 14 At the Interface between Metabolism and Redox Regulation: Sirtuin 1 as Checkpoint for Neurogenesis and Longevity 15 Roles of Hydrogen Peroxide and Peroxiredoxin in the Yeast Replicative Aging Model of Aging and Age-Related Disease Supersulfide-Mediated Signaling during Differentiation and De-Differentiation 16 Supersulfide-Mediated Signaling during Differentiation and De-Differentiation 17 Selenoproteins during Cancer Development and Progression 18 Hypoxia and Regulation of Cancer Stem Cells Redox Medicine 19 Redox Homeostasis and Diseases of Cellular Differentiation 20 Gas Plasma: Innovative Cancer Therapy and Cellular Differentiation in Immuno-Oncology 21 Nutrition-Based Redox Regulation in Fish: Implications for Growth, Development, Health, and Flesh Quality Index