Delta Opioid Receptor Pharmacology and Therapeutic Applications

Description

This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed. Front Matter ....Pages i-viii Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept (Akiyoshi Saitoh, Hiroshi Nagase)....Pages 3-19 Multifunctional Opioid Ligands (Jessica P. Anand, Deanna Montgomery)....Pages 21-51 Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins (Bernard P. Roques)....Pages 53-70 Ligand-Directed Signaling at the Delta Opioid Receptor (Ana Vicente-Sanchez, Amynah A. Pradhan)....Pages 73-85 Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons (Amaury François, Grégory Scherrer)....Pages 87-114 Evidence and Function Relevance of Native DOR–MOR Heteromers (Catherine M. Cahill, Edmund Ong)....Pages 115-127 OPRD1 Genetic Variation and Human Disease (Richard C. Crist, Toni-Kim Clarke)....Pages 131-145 The Delta Opioid Receptor in Pain Control (Khaled Abdallah, Louis Gendron)....Pages 147-177 Delta Opioid Receptors and Modulation of Mood and Emotion (Isaac J. Dripps, Emily M. Jutkiewicz)....Pages 179-197 Delta Opioid Pharmacology in Relation to Alcohol Behaviors (Doungkamol Alongkronrusmee, Terrance Chiang, Richard M. van Rijn)....Pages 199-225 Delta Opioid Receptors: Learning and Motivation (L. P. Pellissier, C. N. Pujol, J. A. J. Becker, J. Le Merrer)....Pages 227-260 Delta Opioid Pharmacology in Parkinson’s Disease (Omar S. Mabrouk)....Pages 261-275 Delta Opioid Receptor and Peptide: A Dynamic Therapy for Stroke and Other Neurological Disorders (M. Grant Liska, Marci G. Crowley, Trenton Lippert, Sydney Corey, Cesar V. Borlongan)....Pages 277-299 Delta Opioid Receptors and Cardioprotection (Louise See Hoe, Hemal H. Patel, Jason N. Peart)....Pages 301-334 The Roles of Opioid Receptors in Cutaneous Wound Healing (Mei Bigliardi-Qi, Paul Bigliardi)....Pages 335-345