ENGLISH

Protein Kinase CK2

Book information

Publisher
Wiley-Blackwell
Year
2012
ISBN
9780470963036, 9781118482490
DOI
10.1002/9781118482490
Language
english
Format
PDF
Filesize
9 MB (9044601 bytes)
Pages
484\484
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

The importance of CK2 in cancer and other diseases has generated a significant amount of literature on the protein, and an international community of CK2 researchers. The International Union of Biochemistry and Molecular Biology (IUMBMB) sponsors periodic international conferences on CK2, making the protein a natural topic for a Wiley-IUBMB publication. Protein Kinase CK2 will deal with structural aspects underlying the constitutive activity of CK2, its specific susceptibility to pharmacological inhibition and its extraordinary pleiotropy. In the second part the fundamental role of CK2 in a wide number of biological functions will be illustrated, while the third part will be devoted to the unusual mode of implication of CK2 in neoplastic transformation, with an appendix reviewing its potential relevance to other pathologies. Content: Chapter 1 Structural Bases of Protein Kinase CK2 Function and Inhibition (pages 1–75): Karsten Niefind and Roberto BattistuttaChapter 2 The Interactome of Protein Kinase CK2 (pages 76–116): Mathias Montenarh and Claudia GotzChapter 3 CK2 Contribution to the Generation of the Human Phosphoproteome (pages 117–128): Luca Cesaro and Mauro SalviChapter 4 CK2 in Embryonic Development (pages 129–168): Laura Macias Alvarez, Jesus Revuelta?Cervantes and Isabel DominguezChapter 5 Protein Kinase CK2: At the Crossroads of Pathways Controlling Cell Proliferation and Survival (pages 169–189): Michelle Gabriel and David W. LitchfieldChapter 6 The Role of Protein Kinase CK2 in the p53 Response (pages 190–204): David W. MeekChapter 7 The Pivotal Role of CK2 in the Kinome?Targeting Hsp90 Chaperone Machinery (pages 205–238): Yoshihiko MiyataChapter 8 CK2: A Global Regulator of Cell Survival (pages 239–266): Barbara Guerra and Olaf?Georg IssingerChapter 9 Specific Features of Plant CK2 (pages 267–289): Marta Riera, Isabel Cristina Velez?Bermudez, Tommaso Legnaioli and Montserrat PagesChapter 10 The Oncogenic Potential of CK2 (pages 292–304): David C. Seldin and Esther Landesman?BollagChapter 11 Addiction of Cancer Cells to CK2: Survival at All Costs or Achilles' Heel? (pages 305–318): Maria RuzzeneChapter 12 CK2 Suppression of Apoptosis and Its Implication in Cancer Biology and Therapy (pages 319–343): Janeen H. Trembley, JingJiang Wu, Gretchen M. Unger, Betsy T. Kren and Khalil AhmedChapter 13 Protein Kinase CK2 in Normal and Malignant Hematopoiesis (pages 344–362): Francesco PiazzaChapter 14 Role of CK2 in the Control of Cell Plasticity in Breast Carcinoma Progression (pages 363–382): Odile Filhol, Alexandre Deshiere and Claude CochetChapter 15 CK2 as a Logical Target in Cancer Therapy: Potential for Combining CK2 Inhibitors with Various Classes of Cancer Therapeutic Agents (pages 383–439): Denis DryginChapter a01 Appendix: CK2 and Its False Sisters: The Recent Solution of a Very “Cold Case” (pages 440–441):

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