Recent Advances in Cannabinoid Physiology and Pathology

Description

The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems. Cannabinoids also play a central role in developmental physiology, management of pain, and shaping of human behaviour. Recent movements towards legalization of marijuana use have bolstered scientific interest in the cannabinoid field and led to research efforts that would unveil multi-faceted effects and mechanisms of cannabinoid presence in different organs and at various stages of development. This book summarizes the recent advances in the field of cannabinoid research at multiple levels of resolution. It spans from systemic effects of cannabinoids on development, physiological function, and prevalent pathophysiological conditions to mechanisms that govern cannabinoid interaction with their relevant protein targets at atomic resolution. This book will be of interest to a specialized audience in the fields of biochemistry, pharmacology and developmental biology but alsoto a wider readership with interest in general physiology and cannabinoid signalling in biological systems. Front Matter ....Pages i-ix Endocannabinoid System Components: Overview and Tissue Distribution (Neal Joshi, Emmanuel S. Onaivi)....Pages 1-12 Physiology of the Endocannabinoid System During Development (Anna N. Bukiya)....Pages 13-37 Cannabinoid Interactions with Proteins: Insights from Structural Studies (Anna N. Bukiya, Alex M. Dopico)....Pages 39-50 Cannabinoid Signaling in Cancer (Subhadip Das, Kirti Kaul, Sanjay Mishra, Manish Charan, Ramesh K. Ganju)....Pages 51-61 Cannabinoids and Cardiovascular System (Alexander I. Bondarenko)....Pages 63-87 Endocannabinoid System and Alcohol Abuse Disorders (Balapal S. Basavarajappa)....Pages 89-127 Genetic Factors in Cannabinoid Use and Dependence (Megan K. Mulligan)....Pages 129-150 Pharmacology of Medical Cannabis (Md Ruhul Amin, Declan W. Ali)....Pages 151-165 Back Matter ....Pages 167-167