ENGLISH

Regulation of Alternative Splicing

By Professor Dr. Philippe Jeanteur (eds.) , T. A. Thanaraj , S. Stamm (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2003
ISBN
978-3-642-07858-3, 978-3-662-09728-1
DOI
10.1007/978-3-662-09728-1
Language
english
Format
PDF
Filesize
6 MB (6703456 bytes)
Series
Progress in Molecular and Subcellular Biology 31
Edition
1
Pages
245\253
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Cell Biology; Biochemistrygeneral; Developmental Biology; Animal Genetics an

Description

The generality and quantitative extent of alternative splicing have only now begun to be fully appreciated. The first draft of the complete human genome led to the surprisingly low figure of about 32,000 genes. The extensive use of alternative splicing and its consequences in terms of coding capacity could account for this discrepancy and help fill the complexity gap between the genome and the proteome. After a computer-based assessment of the frequency of alternative splicing, this book addresses mechanistic aspects followed by examples of its involvement in important cellular processes. Finally, it raises the possibility of artificial modulation of alternative splicing by antisense nucleotides.

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