ENGLISH

Growth Hormone

By John-Olov Jansson , Suzanne L. Dickson (auth.) , Bengt-Åke Bengtsson M.D. (eds.)

Book information

Publisher
Springer US
Year
1999
ISBN
9781461373513, 9781461551638
Language
english
Format
PDF
Filesize
20 MB (21320301 bytes)
Series
Endocrine Updates 4
Edition
1
Pages
359\357
Time added
2020-08-30 06:11:09
Diabetes; Cardiology; Internal Medicine; Orthopedi

Description

Growth Hormone is a fitting addition to the Endocrine Updates Series. The aim of these publications is to provide the clinician with cutting-edge, yet succinct, access to the latest advances in endocrinology. Current interest in this rapidly evolving area of endocrinology makes this a timely and important update. Growth Hormone joins Dr. Fagin's Thyroid Cancer in continuing the standard of excellence as the fourth volume in this series of topical updates. Shlomo Melmed, MD, Series Editor, Endocrine Updates Ten years ago, many endocrinologists were still skeptical that growth hormone (GH) played an active role in adult metabolism. This is, perhaps, surprising given that GH deficiency (GHD) in adulthood had been `recognized' as long ago as the 1960s. During the last ten years studies have shown that GHD in adulthood is a far-reaching syndrome associated with abnormal body composition, reduced bone mineral density with an increased fracture rate, increased cardiovascular morbidity and impaired cardiac function, as well as reduced exercise performance and decreased psychological well-being. Importantly, it is also clear, from placebo-controlled trials, that GH replacement therapy can normalize body composition, increase bone mineral content and improve the cardiovascular risk factor profile. GH replacement therapy also improves cardiac performance and exercise capacity, increases muscle strength and improves well-being and quality of life. The aim of Growth Hormone is to provide a critical update of current knowledge about adult GHD and the future role of GH/IGF-1 in adult medicine. For this purpose, contributions from a number of research groups have been invited. It is my hope that the book may not only serve as an introduction to the field, but also stimulate further research within this exciting area. Front Matter....Pages i-xiii Front Matter....Pages 1-1 Neuroendocrine Control of Growth Hormone Secretion....Pages 3-15 Signal Transduction Through the Growth Hormone Receptor....Pages 17-35 Growth Hormone Binding Proteins....Pages 37-57 Regulation of Insulin-Like Growth Factor-I and its Role in Controlling Growth and Metabolism....Pages 59-75 The Insulin-Like Growth Factor (IGF) Binding Proteins (IGFBPS)....Pages 77-96 The Etiology of Growth Hormone Deficiency in the Human Adult....Pages 97-108 The Diagnosis of Adult Growth Hormone Deficiency....Pages 109-126 Adult Growth Hormone Deficiency — the Clinical Picture....Pages 127-132 Front Matter....Pages 133-133 Effects of GH on Body Composition....Pages 135-148 Effects of GH on Lipid Metabolism....Pages 149-162 The Effects of Growth Hormone on Glucose & Protein Metabolism....Pages 163-172 Effects of Growth Hormone on Blood Coagulation and Fibrinolysis....Pages 173-188 Growth Hormone and the Immune System....Pages 189-225 Effects of Growth Hormone on Muscle Mass and Function....Pages 227-236 Effects of GH on Bone Metabolism and Bone Mass....Pages 237-252 GH Effects on Cardiac Function....Pages 253-260 Psychological Well-Being in Growth Hormone Deficiency and Central Nervous Effects of Growth Hormone....Pages 261-279 Dose Titration and Monitoring GH Treatment in the Adult....Pages 281-290 Side Effects of Growth Hormone Treatment....Pages 291-305 Front Matter....Pages 307-307 Growth Hormone in Heart Failure....Pages 309-323 Front Matter....Pages 307-307 GH and Catabolic States....Pages 325-333 GHRP-GH Secretagogues....Pages 335-351 Back Matter....Pages 353-359

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