ENGLISH

The Cerebral Perivascular Cells

By PD Dr. D. N. Angelov , Dr. M. Walther , Dr. W. F. Neiss , Dr. M. Streppel , Dr. O. Guntinas-Lichius (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1998
ISBN
978-3-540-64638-9, 978-3-642-72251-6
DOI
10.1007/978-3-642-72251-6
Language
english
Format
PDF
Filesize
4 MB (3674344 bytes)
Series
Advances in Anatomy Embryology and Cell Biology 147
Edition
1
Pages
90\95
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Neurosciences; Cell Biology

Description

Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Employing the combination of (a) a lesion model in which neuronal degeneration and neuronophagia are caused without disruption of the blood--brain barrier, (b) stable labeling of the neuronophages via phagocytosis of the permanent nontoxic fluorescent marker Fluoro-Gold from preloaded neurons, and (c) immunocytochemical identification of all FG-labeled brain neuronophages, the authors provide evidence that the only cells in the rat CNS which can be regarded as the resident antigen presenting cells of the brain are perivascular cells.

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