Metabolic Encephalopathy

Description

Metabolic Encephalopathy is meant to combine and correlate animal and human studies. In many cases, alterations in the neurochemistry of humans and experimental animal models is similar. It is hoped that increased awareness of the importance of early diagnosis and treatment of these disorders may result in a lowering of the incidence of structural changes and morbidity. These metabolic encephalopathies hold a special fascination for both basic scientists and clinical investigators because they are accessible, treatable, and there exist good animal models for further study. Therefore, this book assembles both basic and clinical neuroscience issues in the treatment of specific metabolic encephalopathies such as uremia, Wernicke’s disease, epilepsy, stroke, hepatic encephalopathy, pediatric encephalopathies, inborn errors of metabolism, toxins such as lead, depression, cerebral infections, kernicterus, Wilson disease, and many others. About the Editor: Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 23rd year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others. This is his third edited book. Front Matter....Pages i-xvi Functional Anatomy of the Brain....Pages 1-14 Brain Metabolic Adaptations to Hypoxia....Pages 15-30 Hypoglycemic Brain Damage....Pages 31-39 Experimental Ischemia: Summary of Metabolic Encephalopathy....Pages 41-67 Metabolic Encephalopathy Stroke – Clinical Features....Pages 69-83 The Role of Animal Models in the Study of Epileptogenesis....Pages 85-112 Seizure-Induced Neuronal Plasticity and Metabolic Effects....Pages 113-135 Metabolic Encephalopathies in Children....Pages 137-148 Pathophysiology of Hepatic Encephalopathy: Studies in Animal Models....Pages 149-180 Hepatic Encephalopathy....Pages 181-199 Uremic and Dialysis Encephalopathies....Pages 201-234 Thiamine Deficiency: A Model of Metabolic Encephalopathy and of Selective Neuronal Vulnerability....Pages 235-260 Alcohol, Neuron Apoptosis, and Oxidative Stress....Pages 261-279 Wernicke’s Encephalopathy....Pages 281-301 The Genetics of Myelination in Metabolic Brain Disease: The Leukodystrophies....Pages 303-319 Bilirubin Encephalopathy....Pages 321-332 Infectious and Inflammatory Metabolic Encephalopathies....Pages 333-348 Major Depression and Metabolic Encephalopathy: Syndromes More Alike Than Not?....Pages 349-369 Attention-Deficit/Hyperactivity Disorder as a Metabolic Encephalopathy....Pages 371-391 Retracted: Brain Damage in Phenylalanine, Homocysteine and Galactose Metabolic Disorders....Pages 393-457 Wilson Disease....Pages 459-482 Metabolic Abnormalities in Alzheimer Disease....Pages 483-530 Prions and the Transmissible Spongiform Encephalopathies....Pages 531-550 Lead Encephalopathy....Pages 551-571 Back Matter....Pages E1-E1 ....Pages 573-585