ENGLISH

Uremic Toxins and Organ Failure

Book information

Publisher
Springer Singapore;Springer
Year
2020
ISBN
9789811577925, 9789811577932
DOI
10.1007/978-981-15-7793-2
Language
english
Format
PDF
Filesize
5 MB (4963092 bytes)
Edition
1st ed.
Pages
VIII, 180\179
Time added
2021-01-06 05:41:07

Description

This book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.

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