Models of Seizures and Epilepsy

Description

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Content: Front matter,Copyright,Contributors,Foreword,PrefaceEntitled to full textPart I: IntroductionChapter 1 - What Can We Model?, Pages 1-3, Asla Pitkänen, Aristea S. Galanopoulou, Solomon L. Moshé, Paul S. Buckmaster Chapter 2 - Comparative Biology and Species Effects on Expression of Epilepsy, Pages 7-19, Paul S. Buckmaster Chapter 3 - Strain Effects on Expression of Seizures and Epilepsy, Pages 21-38, Wolfgang Löscher, R.J. Ferland, T.N. Ferraro Chapter 4 - Good Welfare Practice in Modeling Seizures and Epilepsy, Pages 39-46, John G.R. Jefferys Chapter 5 - Ethics in the Use of Animal Models of Seizures and Epilepsy, Pages 47-68, Jerrold Tannenbaum Chapter 6 - Regulatory Aspects for Drug Development, Pages 69-82, Lisa D. Coles, Henrik Klitgaard, Marie Kuker, James C. Cloyd Chapter 7 - Use of Animal Models for Epilepsy Research and Therapy Development, Pages 83-94, Melissa Barker-Haliski, H. Steve White Chapter 8 - Monitoring for Seizures in Rodents, Pages 97-109, Edward H. Bertram Chapter 9 - Behavioral Characterization and Scoring of Seizures in Rodents, Pages 111-123, Jana Velíšková, Libor Velíšek Chapter 10 - Seizure Mimics, Pages 125-137, Aristea S. Galanopoulou, Solomon L. Moshé Chapter 11 - Characterization of Pathology, Pages 139-160, Eleonora Aronica, Angelika Mühlebner, Erwin A. van Vliet, Jan A. Gorter Chapter 12 - Monitoring Cardiorespiratory and Other Physiological Parameters During Seizures in Small Animals, Pages 161-179, Mark Stewart, Jeffrey Goodman Chapter 13 - Behavioral and Cognitive Testing Procedures in Animal Models of Epilepsy, Pages 181-196, Andrey M. Mazarati Chapter 14 - In Vivo Imaging in Rodents, Pages 197-215, Olli Gröhn, Steven Deleye, Daniele Bertoglio, Stefanie Dedeurwaerdere Chapter 15 - Hippocampal In Silico Models of Seizures and Epilepsy, Pages 219-232, Ivan Raikov, Ivan Soltesz Chapter 16 - Neocortical/Thalamic In Silico Models of Seizures and Epilepsy, Pages 233-246, Fabrice Wendling, Fabrice Bartolomei, Julien Modolo Chapter 17 - Genetic Epilepsy Modeling With Human Pluripotent Stem Cells, Pages 247-260, Louis T. Dang, Jack M. Parent Chapter 18 - Hippocampus In Vitro, Pages 261-272, Anton I. Ivanov, Christophe Bernard Chapter 19 - Thalamic Models of Seizures In Vitro, Pages 273-284, Frances S. Cho, Alexandra Clemente, Stephanie Holden, Jeanne T. Paz Chapter 20 - Brain Slices From Human Resected Tissues, Pages 285-299, Uwe Heinemann, Siegrun Gabriel, Eskedar A. Angamo, Seda Salar, Thomas-Nicolas Lehmann, Nora Dengler Chapter 21 - Organotypic Hippocampal Slice Cultures as a Model of Posttraumatic Epileptogenesis, Pages 301-311, Yevgeny Berdichevsky, Joseph Glykys, Volodya Dzhala, Kyle Lillis, Kevin J. Staley Chapter 22 - The In Vitro Isolated Guinea Pig Brain in the Study of Ictogenesis, Pages 313-323, Marco de Curtis, Vadym Gnatkovsky, Laura Uva, Laura Librizzi Chapter 23 - Nematode C. elegans: Genetic Dissection of Pathways Regulating Seizure and Epileptic-Like Behaviors, Pages 327-344, Seika Takayanagi-Kiya, Yishi Jin Chapter 24 - Drosophila, Pages 345-358, Richard A. Baines, Carlo N.G. Giachello, Wei-Hsiang Lin Chapter 25 - Xenopus laevis, Pages 359-367, Laura A. Jansen Chapter 26 - Zebrafish Models of Epilepsy and Epileptic Seizures, Pages 369-384, Daniëlle Copmans, Aleksandra Siekierska, Peter A.M. de Witte Chapter 27 - Naturally Occurring Epilepsy and Status Epilepticus in Dogs, Pages 387-398, Heidrun Potschka, Edward N. Patterson, Ilo E. Leppik Chapter 28 - Naturally Occurring Temporal Lobe Epilepsy in Cats, Pages 399-411, Akos Pakozdy, Andrea Klang, Sibylle Kneissl, Peter Halasz Chapter 29 - Naturally Occurring Epilepsy and Status Epilepticus in Sea Lions, Pages 413-425, Paul S. Buckmaster Chapter 30 - Baboon Model of Genetic Generalized Epilepsy, Pages 427-440, Charles Á. Szabó, Felipe S. Salinas Chapter 31 - Genetic Models of Reflex Epilepsy and SUDEP in Rats and Mice, Pages 441-453, Carl Faingold, Srinivasan Tupal, Prosper N’Gouemo Chapter 32 - Genetic Models of Absence Epilepsy in Rats and Mice, Pages 455-471, Guillaume Jarre, Isabelle Guillemain, Colin Deransart, Antoine Depaulis Chapter 33 - Electrical Stimulation Seizure Models, Pages 474-488, Erwin A. van Vliet, Jan A. Gorter Chapter 34 - Systemic Chemoconvulsants Producing Acute Seizures in Adult Rodents, Pages 491-512, Jana Velíšková, Michael P. Shakarjian, Libor Velíšek Chapter 35 - Focally Applied Chemoconvulsants, Pages 513-527, David C. Henshall Chapter 36 - Models of Chemically-Induced Acute Seizures and Epilepsy: Toxic Compounds and Drugs of Addiction, Pages 529-551, Frederic Dorandeu, Guilhem Calas, Gregory Dal Bo, Raafat Fares Chapter 37 - Pharmacologically Induced Animal Models of Absence Seizures, Pages 553-567, George K. Kostopoulos Chapter 38 - Models of Seizures and Status Epilepticus Early in Life, Pages 569-586, Stéphane Auvin, Astrid Nehlig Chapter 39 - Tetanus Toxin, Pages 589-598, Matthew C. Walker, John G.R. Jefferys, Robert C. Wykes Chapter 40 - Post-Status Epilepticus Models: Systemic Kainic Acid, Pages 599-610, F. Edward Dudek, Kevin J. Staley Chapter 41 - Poststatus Epilepticus Models: Focal Kainic Acid, Pages 611-624, David C. Henshall Chapter 42 - The Pilocarpine Model of Acquired Epilepsy, Pages 625-636, Mary E. Kelly, Douglas A. Coulter Chapter 43 - Post-Status Epilepticus Models: Electrical Stimulation, Pages 637-650, Jan A. Gorter, Erwin A. van Vliet Chapter 44 - Poststatus Epilepticus Models: Hyperthermia, Pages 651-660, Nathalie T. Sanon, Tarek Shaker, Lionel Carmant Chapter 45 - Epilepsy After Traumatic Brain Injury, Pages 661-681, Asla Pitkänen, Jenni Kyyriäinen, Pedro Andrade, Lotta Pasanen, Xavier Ekolle Ndode-Ekane Chapter 46 - Postinfectious Epilepsy, Pages 683-696, Dipan C. Patel, Karen S. Wilcox Chapter 47 - Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in Developing Brain, Pages 697-711, Hongyu Sun, Frances E. Jensen Chapter 48 - Perinatal Hypoxic-Ischemic Encephalopathy: A Model of Stroke-Induced Pediatric Epilepsy, Pages 713-725, Jeffrey Bastar, Jay G. Spampanato, Shilpa D. Kadam, Andrew Zayachkivsky, Jeffrey Ekstrand, Kevin J. Staley, F. Edward Dudek Chapter 49 - Poststroke Epilepsy, Pages 727-741, Kevin M. Kelly Chapter 50 - Animal Models of Drug-Refractory Epilepsy, Pages 743-760, Wolfgang Löscher Chapter 51 - Spontaneous and Gene-Directed Epilepsy Mutations in the Mouse, Pages 763-776, Jeffrey L. Noebels Chapter 52 - Dravet and GEFS+ Syndromes, Pages 777-795, Kay L. Richards, Steve Petrou Chapter 53 - Tuberous Sclerosis and Other mTORopathies, Pages 797-810, Anna Jeong, Michael Wong Chapter 54 - Kindling: A Model and Phenomenon of Epilepsy, Pages 813-825, Thomas P. Sutula, Robert J. Kotloski Chapter 55 - Human Mutations Associated With Brain Malformations Resulting in Hyperexcitability in Rodents, Pages 827-844, Valerio Conti, Renzo Guerrini Chapter 56 - Dysplasias: Cortical Freeze Lesion, Pages 845-859, Lauren A. Lau, Chris G. Dulla Chapter 57 - Dysplasia: MAM, Model of Developmental Epilepsy, Pages 861-876, Giorgio Battaglia, Adele Finardi, Paola Nobili, Francesca Colciaghi Chapter 58 - In Utero Irradiation as a Model of Cortical Dysplasia, Pages 877-885, Dean D. Lin, Steven N. Roper Chapter 59 - Undercut Cortex, Pages 887-898, Xiaoming Jin, Xingjie Ping Chapter 60 - Brain Tumor-Related Epilepsy, Pages 899-910, Rüdiger Köhling Chapter 61 - Withdrawal Seizures, Pages 911-931, Jamila Newton, Prosper N’Gouemo Chapter 62 - Perimenstrual Seizures and Neurosteroid Withdrawal, Pages 933-940, Doodipala S. Reddy Chapter 63 - Metabolic Disturbances: Hypo- and Hyperglycemic Seizures In Vivo and In Vitroa, Pages 941-949, Peter L. Carlen, Liang Zhang Chapter 64 - Blood–Brain Barrier Disruption, Pages 951-959, Dan Z. Milikovsky, Daniela Kaufer, Alon Friedman Chapter 65 - Experimental Models of Inflammation in Epilepsy Research, Pages 961-974, Teresa Ravizza, Silvia Balosso, Nicola Marchi Chapter 66 - Infantile Spasms, Pages 977-993, Aristea S. Galanopoulou, Solomon L. Moshé Chapter 67 - Models of Epileptic Encephalopathies, Pages 995-1005, Paul R. Jarvis, Gregory L. Holmes Chapter 68 - SUDEP Animal Models, Pages 1007-1018, Alica M. Goldman, Gordon Buchanan, Isamu Aiba, Jeffrey L. Noebels Chapter 69 - Epilepsy in Models of Alzheimer’s Disease, Pages 1021-1030, Heikki Tanila, Asla Pitkänen Chapter 70 - Animal Models of Acquired Epilepsy and Tauopathies, Pages 1031-1041, Ping Zheng, Sandy Shultz, Chris Hovens, Terence J. O’Brien Chapter 71 - Epilepsy in Other Neurodegenerative Disorders: Huntington’s and Parkinson’s Diseases, Pages 1043-1058, Ana M. Estrada-Sánchez, Michael S. Levine, Carlos Cepeda Chapter 72 - Autism and Fragile X Syndrome, Pages 1059-1078, Heather O’Leary, Tim Benke Chapter 73 - Epilepsy in Models of Rett Syndrome, Pages 1079-1090, James H. Eubanks Chapter 74 - Models of Depressiona, Pages 1091-1104, Andrey M. Mazarati Chapter 75 - What Do Models Model? What Needs to Be Modeled?, Pages 1107-1119, Aristea S. Galanopoulou, Asla Pitkänen, Paul S. Buckmaster, Solomon L. Moshé Index, Pages 1121-1151