ENGLISH

Next Generation Sequencing Technologies and Challenges in Sequence Assembly

By Sara El-Metwally , Osama M. Ouda , Mohamed Helmy (auth.)

Book information

Publisher
Springer-Verlag New York
Year
2014
ISBN
978-1-4939-0714-4, 978-1-4939-0715-1
DOI
10.1007/978-1-4939-0715-1
Language
english
Format
PDF
Filesize
2 MB (1587806 bytes)
Series
SpringerBriefs in Systems Biology 7
Edition
1
Pages
118\123
Time added
2014-06-12 06:00:00
Systems Biology; Human Genetics; Bioinformatics

Description

The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.

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