ENGLISH

The Biology of mRNA: Structure and Function

By Marlene Oeffinger , Daniel Zenklusen

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-030-31433-0, 978-3-030-31434-7
Language
english
Format
PDF
Filesize
7 MB (7270891 bytes)
Series
Advances in Experimental Medicine and Biology 1203
Edition
1st ed. 2019
Pages
VIII, 312\318
Time added
2020-02-08 04:41:56
Biomedicine; Molecular Medicine; Gene Expression;

Description

The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. This book shows how new technologies have led to a better understanding of these processes and their connected diseases.The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology. Front Matter ....Pages i-viii Mechanism and Regulation of Co-transcriptional mRNP Assembly and Nuclear mRNA Export (Wolfgang Wende, Peter Friedhoff, Katja Sträßer)....Pages 1-31 It’s Not the Destination, It’s the Journey: Heterogeneity in mRNA Export Mechanisms (Daniel D. Scott, L. Carolina Aguilar, Mathew Kramar, Marlene Oeffinger)....Pages 33-81 View from an mRNP: The Roles of SR Proteins in Assembly, Maturation and Turnover (Marius Wegener, Michaela Müller-McNicoll)....Pages 83-112 The Nuclear RNA Exosome and Its Cofactors (Manfred Schmid, Torben Heick Jensen)....Pages 113-132 3′-UTRs and the Control of Protein Expression in Space and Time (Traude H. Beilharz, Michael M. See, Peter R. Boag)....Pages 133-148 Communication Is Key: 5′–3′ Interactions that Regulate mRNA Translation and Turnover (Hana Fakim, Marc R. Fabian)....Pages 149-164 Bioinformatics Approaches to Gain Insights into cis-Regulatory Motifs Involved in mRNA Localization (Louis Philip Benoit Bouvrette, Mathieu Blanchette, Eric Lécuyer)....Pages 165-194 RNA Granules and Their Role in Neurodegenerative Diseases (Hadjara Sidibé, Christine Vande Velde)....Pages 195-245 Lessons from (pre-)mRNA Imaging (Srivathsan Adivarahan, Daniel Zenklusen)....Pages 247-284 Diverging RNPs: Toward Understanding lncRNA-Protein Interactions and Functions (Martin Sauvageau)....Pages 285-312

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