Miniature Fluidic Devices for Rapid Biological Detection

Description

This book presents an overview of fundamental aspects of surface-based biosensors and techniques for enhancing their detection sensitivity and speed. It focuses on rapid detection using miniaturized sensors and describes the physical principles of nanoscale transducers, surface modifications, microfluidics and reaction engineering, diffusion and kinetics. A key challenge in the field of bioanalytical sensors is the rapid delivery of target biomolecules to the sensing surface. While various nanostructures have shown great promise in sensitive detection, diffusion-limited binding of analyte molecules remains a fundamental problem. Recently, many researchers have put forward novel schemes to overcome this challenge, such as nanopore channels, electrokinetics, and dielectrophoresis, to name but a few. This book provides the readers an up-to-date account on these technological advances. Front Matter ....Pages i-vii Nanopore Membranes for Separation and Sensing (Gustav Emilsson, Andreas B. Dahlin)....Pages 1-23 Nanoporous Gold Nanoparticles and Arrays for Label-Free Nanoplasmonic Biosensing (Camille G. Artur, Wei-Chuan Shih)....Pages 25-67 Microfluidic Mixing for Biosensors (N. Scott Lynn Jr.)....Pages 69-103 Self-directed Transport on Nanostructured Plasmonic Sensors (Shailabh Kumar)....Pages 105-122 Enhanced Plasmonic Detection with Dielectrophoretic Concentration (Avijit Barik, Sang-Hyun Oh)....Pages 123-146 An Introduction to Lensless Digital Holographic Microscopy (Nathan C. Lindquist)....Pages 147-170 Biosensing on Digital Microfluidics: From Sample Preparation to Detection (Ehsan Samiei, Mina Hoorfar)....Pages 171-205 Miniature Fluidic Microtissue Culturing Device for Rapid Biological Detection (Patrick M. Misun, Andreas Hierlemann, Olivier Frey)....Pages 207-225 Back Matter ....Pages 227-229