Spherical Crystallization as a New Platform for Particle Design Engineering

Description

This book describes the principles and applications of the spherical crystallization technique, from the standpoint of its inventor. After an introduction on the history of particle design engineering and nanotechnology, the concept of spherical crystallization itself is clearly explained. Attention then turns to the application of spherical crystallization in pharmaceutical processes. It is explained how the technique can provide physicochemical properties suitable for direct tableting of active pharmaceutical ingredients and how it has enabled the development of a novel particulate design platform from single to complex system. Subsequent chapters describe the roles of polymeric spherical crystallization in the preparation of novel microspheres, microballoons for drug delivery systems (DDS) and the development of biocompatible and biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanospheres. The various applications of PLGA nanospheres composite within oral-, pulmonary-, transdermal DDS and cosmetics are fully discussed. Finally, future perspectives are presented on use of the technology in the design and industrial-scale manufacture of new drug delivery systems, highlighting how a continuous pharmaceutical process that meets US Food and Drug Administration quality requirements should soon be introduced. Front Matter ....Pages i-xvii Introduction (Yoshiaki Kawashima)....Pages 1-9 Concept of Spherical Crystallization (Yoshiaki Kawashima)....Pages 11-18 Paradigm Shifted Pharmaceutical Process Introduced by Spherical Crystallization (Yoshiaki Kawashima)....Pages 19-33 Particulate-Design Platform Developed by the Advanced Spherical Crystallization System (Yoshiaki Kawashima)....Pages 35-58 Development of Novel Microsphere and Microballoon DDSs by Polymeric Spherical Crystallization (Yoshiaki Kawashima)....Pages 59-76 Development of a PLGA-Nanosphere DDS Prepared by Spherical Crystallization with a Polymer (Yoshiaki Kawashima)....Pages 77-97 Application of PLGA NSs to Cosmetics (Yoshiaki Kawashima)....Pages 99-106 Future Perspectives of PLGA Nanospheres for Advanced DDSs and Continuous Preparation Systems for Spherical Crystallizers (Yoshiaki Kawashima)....Pages 107-118