ENGLISH

Diverse effects of hypoxia on tumor progression

By Alexander Pietras , A. Sofie Johnsson (auth.) , M. Celeste Simon (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2010
ISBN
9783642133299, 3642133290
DOI
10.1007/978-3-642-13329-9
Language
english
Format
PDF
Filesize
2 MB (2221255 bytes)
Series
Current Topics in Microbiology and Immunology 345
Edition
1
Pages
146\148
Library
usenet tech
Time added
2013-03-30 20:00:00
Cancer Research; Embryology; Human Physiology

Description

Solid tumors frequently contain areas of oxygen deprivation (hypoxia) due to rapid cell proliferation and/or vascular insufficiency. The presence of hypoxic domains typically correlates with poor patient prognosis, due to the relative resistance of hypoxic cells to conventional cancer therapies and effects of O2 availability on disease progression. The response of malignant cells to hypoxia has been the focus of intense research over the last decade. In this issue of Current Topics in Microbiology and Immunology, the authors present articles describing the impact of hypoxia on components of the tumor microenvironment (such as endothelial cells, inflammatory cells, and tumor associated fibroblasts), the expression of unique microRNAs, tumor cell differentiation status, and metastasis. Each review article describes the state of the field studying these topics, and poses important questions for the future. The overall goal is to depict tumor phenotypes and associated molecular pathways to be exploited in the development of novel therapeutics to be used against a broad spectrum of human cancers.

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