Chordomas: Technologies, Techniques, and Treatment Strategies

Description

A rare form of cancer, chordomas are among the most difficult tumors to treat, requiring highly specialized training and surgical expertise. Although generally slow-growing, chordomas present resection challenges due to their proximity to critical structures including the spinal cord, brainstem, nerves, and arteries. Written by an impressive cadre of internationally-renowned experts, this textbook is the most current, concise, and definitive resource on diagnosis and management of this complex pathology. Acclaimed surgeons from Brazil, Canada, Japan, Turkey, the USA, and the UK are contributors. The book starts with a historical overview, epidemiology, molecular pathogenesis, cytogenetics, local invasion and metastasis, and pathology. A thorough discussion covers diagnostic radiological and radionuclide imaging such as MRI, PET; SPECT, PET-CT, and PET-MRI, and clinical traits of skull base and spinal chordomas as defined by imaging modalities. Subsequent chapters explore decision making including selecting the most optimal techniques, surgical procedures, specialized topics, and new horizons in chordoma treatment. Key Highlights: * Anterior and anterolateral approaches to the clivus. * The use of endoscopy and intraoperative assistive technologies. * Midline subfrontal, middle fossa, extended petrosal, and transcondylar approaches. * Craniospinal fusion techniques following resection. * Surgery for spinal chordomas from the cervical to the sacral region. * Special topics such as radiation, proton beam therapy, Gamma-Knife radiosurgery, and pediatric chordomas and chondrosarcomas This is an essential text for neurosurgeons, orthopedic spine surgeons, otolaryngologists, and radiation oncologists. Read and learn from innovators who have mastered the latest state-of-the-art treatment methodologies for chordomas. Chordomas: Technologies, Techniques, and Treatment Strategies Title Page Copyright Contents Foreword Preface List of Contributors Part I Definition, History, Demographics, Pathology, and Pathogenesis 1 Historical Aspects 2 The Descriptive Epidemiology of Chordomas 3 Evolutionary Origin of the Notochord 4 Molecular Biology of Chordomas 5 Cytogenetics of Chordomas 6 Local Invasion and Metastasis 7 Pathology 8 Experimental Models of Chordomas Part II Diagnosis of Chordomas 9 Radiologic Findings and Differential Diagnosis of Chordomas at the Skull Base 10 Radiologic Findings and Differential Diagnosis of Chordomas in the Spine 11 Molecular Imaging of Chordomas Part III Surgical Treatment of Chordomas 12 Surgical Decision Making in Chordomas 13 Choice of the Optimal Surgical Approach for Skull Base Chordomas 14 Anterior Approaches to the Clivus 15 Endoscopic Approaches for Skull Base Chordomas 16 Frontobasal Approaches to Clival Chordomas 17 Cranio-Orbital–Zygomatic Approach for Chordomas 18 Epidural Middle Fossa Approaches 19 The Extended Petrosal Middle Fossa Approach 20 The Transcondylar Approach to the Clivus 21 Craniovertebral Reconstruction after Chordoma Resection 22 Surgery for Spinal Chordomas 23 Intraoperative Assistive Technologies for Chordoma Surgery Part IV Special Topics in Chordomas 24 Chordomas: A Personal Perspective 25 Radiation Treatment for Chordomas 26 Charged Particle Beams in Management of Clival Chordomas 27 Stereotactic Radiosurgery for Chordomas 28 Recurrence in Skull Base Chordomas and its Management 29 Outcome and Quality of Life of Patients with Chordomas 30 Chordomas and Chondrosarcomas in the Pediatric Population 31 Future Prospects in the Treatment of Skull Base Chordomas Index